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A diffusion tensor-...
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Diczfalusy, ElinLinköpings universitet,Biomedicinsk instrumentteknik,Tekniska högskolan
(author)
A diffusion tensor-based finite element model of microdialysis in the deep brain
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2013-04-29
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Taylor & Francis,2015
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-91886
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-91886URI
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https://doi.org/10.1080/10255842.2013.789103DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Microdialysis of the basal ganglia was recently used to study neurotransmitter levels in relation to deep brain stimulation. In order to estimate the anatomical origin of the obtained data, the maximum tissue volume of influence (TVImax) for a microdialysis catheter was simulated using the finite element method. This study investigates the impact of brain heterogeneity and anisotropy on the TVImax using diffusion tensor imaging (DTI) to create a second-order tensor model of the basal ganglia. Descriptive statistics showed that the maximum migration distance for neurotransmitters varied by up to 55% (n = 98,444) for DTI-based simulations compared with an isotropic reference model, and the anisotropy differed between different targets in accordance with theory. The size of the TVImax was relevant in relation to the size of the anatomical structures of interest, and local tissue properties should be accounted for when relating microdialysis data to their anatomical targets.
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Andersson, MatsLinköpings universitet,Medicinsk informatik,Tekniska högskolan(Swepub:liu)matan45
(author)
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Wårdell, KarinLinköpings universitet,Biomedicinsk instrumentteknik,Tekniska högskolan,Centrum för medicinsk bildvetenskap och visualisering, CMIV,MINT(Swepub:liu)karwa46
(author)
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Linköpings universitetBiomedicinsk instrumentteknik
(creator_code:org_t)
Related titles
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In:Computer Methods in Biomechanics and Biomedical Engineering: Taylor & Francis18:2, s. 201-2121025-58421476-8259
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