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  • Tedeholm, Helen,1978Sahlgrens University Hospital, Sweden,Göteborgs universitet,University of Gothenburg (author)

Time to secondary progression in patients with multiple sclerosis who were treated with first generation immunomodulating drugs

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2012-11-01
  • SAGE Publications (UK and US),2013
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-93965
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-93965URI
  • https://doi.org/10.1177/1352458512463764DOI
  • https://research.chalmers.se/publication/204413URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:126729745URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-187971URI
  • https://gup.ub.gu.se/publication/204413URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Swedish||Gothenburg Multiple Sclerosis Societies||Bayer Schering Pharma||Biogen Idec||Novartis||Sanofi-Aventis||BiogenIdec||Merck-Serono||Bayer-Schering||Teva||Swedish Research Council||Gothenburg Societies of the Neurologically Disabled||
  • Background: It is currently unknown whether early immunomodulatory treatment in relapsing-remitting MS (RRMS) can delay the transition to secondary progression (SP). less thanbrgreater than less thanbrgreater thanObjective: To compare the time interval from onset to SP in patients with RRMS between a contemporary cohort, treated with first generation disease modifying drugs (DMDs), and a historical control cohort. less thanbrgreater than less thanbrgreater thanMethods: We included a cohort of contemporary RRMS patients treated with DMDs, obtained from the Swedish National MS Registry (disease onset between 1995-2004, n = 730) and a historical population-based incidence cohort (onset 1950-64, n = 186). We retrospectively analyzed the difference in time to SP, termed the "period effect" within a 12-year survival analysis, using Kaplan-Meier and Cox regression analysis. less thanbrgreater than less thanbrgreater thanResults: We found that the "period" affected the entire severity spectrum. After adjusting for onset features, which were weaker in the contemporary material, as well as the therapy initiation time, the DMD-treated patients still exhibited a longer time to SP than the controls (hazard ratios: men, 0.32; women, 0.53). less thanbrgreater than less thanbrgreater thanConclusion: Our results showed there was a longer time to SP in the contemporary subjects given DMD. Our analyses suggested that this effect was not solely driven by the inclusion of benign cases, and it was at least partly due to the long-term immunomodulating therapy given.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Lycke, Jan,1956Sahlgrens University Hospital, Sweden,Göteborgs universitet,University of Gothenburg(Swepub:gu)xlycja (author)
  • Skoog, BengtSahlgrens University Hospital, Sweden,Göteborgs universitet,University of Gothenburg(Swepub:gu)xskben (author)
  • Lisovskaja, Vera,1984Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,Chalmers, Sweden(Swepub:cth)vera (author)
  • Hillert, JKarolinska Institutet,Karolinska University Hospital, Sweden (author)
  • Dahle, CharlotteÖstergötlands Läns Landsting,Linköpings universitet,Klinisk immunologi,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin,Linköping University(Swepub:liu)chada46 (author)
  • Fagius, JanUppsala universitet,Neurologi,Karolinska University Hospital, Sweden(Swepub:uu)janfagiu (author)
  • Fredrikson, SKarolinska Institutet,Karolinska University Hospital, Sweden (author)
  • Landtblom, Anne-MarieÖstergötlands Läns Landsting,Linköpings universitet,Neurologi,Hälsouniversitetet,Neurologiska kliniken,Linköping University(Swepub:liu)annla55 (author)
  • Malmeström, Clas,1965Sahlgrens University Hospital, Sweden,Göteborgs universitet,University of Gothenburg(Swepub:gu)xmalcl (author)
  • Martin, CKarolinska Institutet,University Hospital, Sweden (author)
  • Piehl, FKarolinska Institutet,Karolinska University Hospital, Sweden (author)
  • Runmarker, BSahlgrens University Hospital, Sweden,Göteborgs universitet,University of Gothenburg (author)
  • Stawiarz, LKarolinska Institutet,Karolinska University Hospital, Sweden (author)
  • Vrethem, MagnusÖstergötlands Läns Landsting,Linköpings universitet,Neurologi,Hälsouniversitetet,Neurologiska kliniken,Linköping University(Swepub:liu)magvr07 (author)
  • Nerman, Olle,1951Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,Chalmers, Sweden(Swepub:gu)xnerol (author)
  • Andersen, Oluf,1941Sahlgrens University Hospital, Sweden,Göteborgs universitet,University of Gothenburg(Swepub:gu)xandeo (author)
  • Sahlgrens University Hospital, SwedenGöteborgs universitet (creator_code:org_t)

Related titles

  • In:Multiple Sclerosis Journal: SAGE Publications (UK and US)19:6, s. 765-7741352-45851477-0970

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