Leptin and adiponectin in cord blood from children of normal weight, overweight and obese mothers

Brynhildsen, Jan (author): Östergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping,Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences; Linköping University, Linköping, Sweden; Department of Obstetrics and Gynaecology in Linköping, County Council of Östergötland, Linköping, Sweden

Sydsjö, Gunilla (author): Östergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping,Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences; Linköping University, Linköping, Sweden; Department of Obstetrics and Gynaecology in Linköping, County Council of Östergötland, Linköping, Sweden

Blomberg, Marie (author): Östergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping,Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences; Linköping University, Linköping, Sweden; Department of Obstetrics and Gynaecology in Linköping, County Council of Östergötland, Linköping, Sweden

Claesson, Ing-Marie (author): Östergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping,Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences; Linköping University, Linköping, Sweden; Department of Obstetrics and Gynaecology in Linköping, County Council of Östergötland, Linköping, Sweden

Theodorsson, Elvar (author): Östergötlands Läns Landsting,Linköpings universitet,Klinisk kemi,Hälsouniversitetet,Division of Laboratory, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden

Nyström, Fredrik H. (author): Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Endokrinmedicinska kliniken,Division of Internal Medicine, Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden

Sydsjö, Adam (author): Östergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping,Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences; Linköping University, Linköping, Sweden; Department of Obstetrics and Gynaecology in Linköping, County Council of Östergötland, Linköping, Sweden

Josefsson, Ann (author): Östergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping,Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences; Linköping University, Linköping, Sweden; Department of Obstetrics and Gynaecology in Linköping, County Council of Östergötland, Linköping, Sweden

(creator_code:org_t)

2013-03-06
2013
English.
In: Acta Paediatrica. - : Wiley-Blackwell. - 0803-5253 .- 1651-2227. ; 102:6, s. 620-624

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; https://urn.kb.se/re...; show less...

Abstract Subject headings

Aim To study cord blood concentrations of adiponectin and leptin in children born by normal weight, overweight and obese mothers and to study these parameters in relation to a weight gain intervention programme for obese mothers. Methods Ten millilitre cord blood was collected and analysed for leptin and adiponectin concentrations in children with gestational age andgt;37weeks born by 60 normal weight, 45 overweight and 145 obese mothers. 82 obese mothers took part in a weight gain intervention programme. Results Concentrations of leptin and adiponectin were higher in cord blood from children of overweight and obese mothers compared with children of normal weight mothers (leptin: Md 13.2, 30, 3 and 90.2ng/mL respectively, pandlt;0.001; adiponectin 35.9, 205.4, 213.8ng/L pandlt;0.001). No differences were found between overweight and obese mothers. The weight gain intervention programme for obese pregnant women had significant effects on the weight gain during pregnancy but had no effects on cord blood serum concentrations of leptin and adiponectin. Conclusion Cord blood leptin and adiponectin concentrations were higher in children born by overweight or obese women compared with children of normal weight mothers. A weight gain intervention programme for obese pregnant women did not affect these results. Intrauterine exposition to high concentrations of leptin and adiponectin may play a role in weight development later in life.

By the author/editor: Brynhildsen, Jan; Sydsjö, Gunilla; Blomberg, Marie; Claesson, Ing-Ma ...; Theodorsson, Elv ...; Nyström, Fredrik ...; show more...; Sydsjö, Adam; Josefsson, Ann; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Pediatrics

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