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- Zhang, DanSichuan University, Chengdu, Sichuan Province, China (author)
Polymorphisms of Glucose-Regulated Protein 78 and Risk of Colorectal Cancer : A Case-Control Study in Southwest China
- Article/chapterEnglish2013
Publisher, publication year, extent ...
- 2013-06-20
- Public Library of Science,2013
- electronicrdacarrier
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- LIBRIS-ID:oai:DiVA.org:liu-97675
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-97675URI
- https://doi.org/10.1371/journal.pone.0066791DOI
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- Language:English
- Summary in:English
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- Funding Agencies|Outstanding Doctoral Dissertation Foundation of Ministry of Education of China|2007B66|
- Glucose-regulated protein 78 (GRP78), an endoplasmic reticulum chaperone, up-regulation serves as an efficient mechanism to promote malignant transformation of colorectal cancer (CRC) and protect CRC cells against apoptosis. Recently, the analysis of GRP78 polymorphisms has already determined that GRP78 rs391957 polymorphism could predict clinical outcome in CRC patients. Thus, we tested whether GRP78 polymorphisms are related to the risk of CRC. In this study, we detected two GRP78 polymorphisms (rs391957 (C>T) and rs430397 (G>A)) in 414 CRC cases and 502 hospital-based cancer-free healthy controls in Southwest China using a polymerase chain reaction–restriction fragment length polymorphism technique. Compared with the CC genotype, carriers of CT and TT genotypes of rs391957 polymorphism had higher risks of CRC (odds ratio (OR) = 1.39, 95% confidence interval (CI) = 1.06–1.83 for CT genotype and OR = 2.10, 95% CI = 1.06–4.14 for TT genotype, respectively). In CRC cases, the variant T allele was significantly associated with tumor invasion stage (P = 0.030), but not with status of lymph nodes metastasis (P = 0.052). Compared with the GG genotype, carriers of GA and AA genotypes of rs430397 polymorphism had higher risks of CRC (OR = 1.63, 95% CI = 1.23–2.15 for GA genotype and OR = 2.92, 95% CI = 1.23–6.94 for AA genotype, respectively). The rs430397 polymorphism was not associated with the clinicopathological characteristics of CRC. These data provide the first evidence that GRP78 rs391957 and rs430397 polymorphisms could serve as markers to predict the risk of CRC.
Subject headings and genre
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Zhou, BinSichuan University, Chengdu, Sichuan Province, China (author)
- Li, YuanSichuan University, Chengdu, Sichuan Province, China (author)
- Wang, MojinSichuan University, Chengdu, Sichuan Province, China (author)
- Wang, CunSichuan University, Chengdu, Sichuan Province, China (author)
- Zhou, ZongguangSichuan University, Chengdu, Sichuan Province, China (author)
- Sun, Xiao-FengÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Onkologiska kliniken US(Swepub:liu)xiasu45 (author)
- Sichuan University, Chengdu, Sichuan Province, ChinaAvdelningen för kliniska vetenskaper (creator_code:org_t)
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- In:PLOS ONE: Public Library of Science8:61932-6203
Internet link
- https://doi.org/10.1371/journal.pone.0066791Fulltext
- https://liu.diva-portal.org/smash/get/diva2:649968/FULLTEXT01.pdffulltext:print
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0066791&type=printable
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-97675
- https://doi.org/10.1371/journal.pone.0066791
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