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  • Holt, Margrethe FlesvigOslo Univ Hosp, Norway;Oslo University Hospital Rikshospitalet, Norway (author)

The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-12-24
  • Frontiers Media S.A.2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:lnu-109893
  • https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-109893URI
  • https://doi.org/10.3389/fimmu.2021.800978DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Objective: Dysregulation of the complement system has been described in patients with heart failure (HF). However, data on the alternative pathway are scarce and it is unknown if levels of factor B (FB) and the C3 convertase C3bBbP are elevated in these patients. We hypothesized that plasma levels of FB and C3bBbP would be associated with disease severity and survival in patients with HF. Methods: We analyzed plasma levels of FB, C3bBbP, and terminal C5b-9 complement complex (TCC) in 343 HF patients and 27 healthy controls. Results: Compared with controls, patients with HF had elevated levels of circulating FB (1.6-fold, p < 0.001) and C3bBbP (1.3-fold, p < 0.001). In contrast, TCC, reflecting the terminal pathway, was not significantly increased (p = 0.15 vs controls). FB was associated with NT-proBNP, troponin, eGFR, and i.e., C-reactive protein. FB, C3bBbP and TCC were not associated with mortality in HF during a mean follow up of 4.3 years. Conclusion: Our findings suggest that in patients with HF, the alternative pathway is activated. However, this is not accompanied by activation of the terminal pathway.

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  • Michelsen, Annika E.Oslo Univ Hosp, Norway;Univ Oslo, Norway (author)
  • Shahini, NegarOslo Univ Hosp, Norway (author)
  • Bjorkelund, ElisabethOslo University Hospital Rikshospitalet, Norway (author)
  • Bendz, Christina HoltOslo University Hospital Rikshospitalet, Norway (author)
  • Massey, Richard J.Oslo University Hospital Rikshospitalet, Norway;Univ Oslo, Norway (author)
  • Schjalm, CamillaOslo University Hospital Rikshospitalet, Norway;Univ Oslo, Norway (author)
  • Halvorsen, BenteOslo Univ Hosp, Norway;Univ Oslo, Norway (author)
  • Broch, KasparOslo University Hospital Rikshospitalet, Norway;Univ Oslo, Norway (author)
  • Ueland, ThorOslo Univ Hosp, Norway;Univ Oslo, Norway;The Arctic University of Norway, Norway (author)
  • Gullestad, LarsOslo University Hospital Rikshospitalet, Norway;Univ Oslo, Norway (author)
  • Nilsson, Per H.,1980-Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Avancerade material,Oslo University Hospital Rikshospitalet, Norway;University of Oslo, Norway,Linnaeus Ctr Biomat Chem, BMC;HoRB(Swepub:lnu)enipe (author)
  • Aukrust, PålOslo University Hospital Rikshospitalet, Norway;University of Oslo, Norway (author)
  • Mollnes, Tom EirikOslo University Hospital Rikshospitalet, Norway;University of Oslo, Norway;The Arctic University of Norway, Norway;Nordland Hospital, Norway;Norwegian University of Science and Technology, Norway (author)
  • Louwe, Mieke C.Oslo University Hospital, Norway (author)
  • Oslo Univ Hosp, Norway;Oslo University Hospital Rikshospitalet, NorwayOslo Univ Hosp, Norway;Univ Oslo, Norway (creator_code:org_t)

Related titles

  • In:Frontiers in Immunology: Frontiers Media S.A.121664-3224

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