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Oxytocin-Selective ...
Oxytocin-Selective Nanogel Antibody Mimics
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- Mahajan, Rashmi (author)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Linnaeus Ctr Biomat Chem, BMC;BBCL,Linnaeus Univ, Ctr Biomat Chem, Dept Chem & Biomed Sci, Bioorgan & Biophys Chem Lab, S-39182 Kalmar, Sweden.
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- Suriyanarayanan, Subramanian (author)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Linnaeus Ctr Biomat Chem, BMC;BBCL,Linnaeus Univ, Ctr Biomat Chem, Dept Chem & Biomed Sci, Bioorgan & Biophys Chem Lab, S-39182 Kalmar, Sweden.
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- Olsson, Gustaf D. (author)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Linnaeus Ctr Biomat Chem, BMC;BBCL,Linnaeus Univ, Ctr Biomat Chem, Dept Chem & Biomed Sci, Bioorgan & Biophys Chem Lab, S-39182 Kalmar, Sweden.
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- Wiklander, Jesper G., 1974- (author)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Linnaeus Ctr Biomat Chem, BMC;BBCL,Linnaeus Univ, Ctr Biomat Chem, Dept Chem & Biomed Sci, Bioorgan & Biophys Chem Lab, S-39182 Kalmar, Sweden.
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- Aastrup, Teodor (author)
- Attana AB, Greta Arwidssons Vag 21, S-11419 Stockholm, Sweden.
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- Sellergren, Börje (author)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Malmö University, Sweden
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- Nicholls, Ian A. (author)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Avancerade material,Linnaeus Ctr Biomat Chem, BMC;BBCL,Linnaeus Univ, Ctr Biomat Chem, Dept Chem & Biomed Sci, Bioorgan & Biophys Chem Lab, S-39182 Kalmar, Sweden.
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(creator_code:org_t)
- 2022-02-25
- 2022
- English.
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In: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 23:5
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Abstract
Subject headings
Close
- Oxytocin imprinted polymer nanoparticles were synthesized by glass bead supported solid phase synthesis, with NMR and molecular dynamics studies used to investigate monomer-template interactions. The nanoparticles were characterized by dynamic light scattering, scanning- and transmission electron microscopy and X-ray photoelectron spectroscopy. Investigation of nanoparticle-template recognition using quartz crystal microbalance-based studies revealed sub-nanomolar affinity, k(d) approximate to 0.3 +/- 0.02 nM (standard error of the mean), comparable to that of commercial polyclonal antibodies, k(d) approximate to 0.02-0.2 nM.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- molecular dynamics
- molecularly imprinted polymer
- nanoparticle
- NMR
- peptide imprinting
- plastic antibody
- oxytocin
- solid-phase synthesis
- QCM
- Biokemi
- Biochemistry
Publication and Content Type
- ref (subject category)
- art (subject category)
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