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The effect of intri...
The effect of intrinsically photosensitive retinal ganglion cell (ipRGC) stimulation on axial length changes to imposed optical defocus in young adults
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- Chakraborty, Ranjay (author)
- Flinders University, Australia
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- Collins, Michael J. (author)
- Queensland University of Technology, Australia
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- Kricancic, Henry (author)
- Queensland University of Technology, Australia
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- Davis, Brett (author)
- Queensland University of Technology, Australia
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- Alonso-Caneiro, David (author)
- Queensland University of Technology, Australia
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- Yi, Fan (author)
- Queensland University of Technology, Australia
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- Baskaran, Karthikeyan, Senior Lecturer, 1983- (author)
- Linnéuniversitetet,Institutionen för medicin och optometri (MEO)
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- English.
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In: Journal of Optometry. - : Elsevier. - 1888-4296. ; 16:1, s. 53-63
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Purpose: The intrinsically photosensitive retinal ganglion cells (ipRGCs) regulate pupil size and circadian rhythms. Stimulation of the ipRGCs using short-wavelength blue light causes a sustained pupil constriction known as the post-illumination pupil response (PIPR). Here we examined the effects of ipRGC stimulation on axial length changes to imposed optical defocus in young adults.Materials and methods: Nearly emmetropic young participants were given either myopic (+3 D, n = 16) or hyperopic (-3 D, n = 17) defocus in their right eye for 2 h. Before and after defocus, a series of axial length measurements for up to 180 s were performed in the right eye using the IOL Master following exposure to 5 s red (625 nm, 3.74 × 1014 photons/cm2/s) and blue (470 nm, 3.29 × 1014 photons/cm2/s) stimuli. The pupil measurements were collected from the left eye to track the ipRGC activity. The 6 s and 30 s PIPR, early and late area under the curve (AUC), and time to return to baseline were calculated.Results: The PIPR with blue light was significantly stronger after 2 h of hyperopic defocus as indicated by a lower 6 and 30 s PIPR and a larger early and late AUC (all p<0.05). Short-wavelength ipRGC stimulation also significantly exaggerated the ocular response to hyperopic defocus, causing a significantly greater increase in axial length than that resulting from the hyperopic defocus alone (p = 0.017). Neither wavelength had any effect on axial length with myopic defocus.Conclusions: These findings suggest an interaction between myopiagenic hyperopic defocus and ipRGC signaling.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Keyword
- Intrinsically photosensitive retinal ganglion cells
- Axial length
- Melanopsin
- Optical defocus
- Myopia
- Optometry
- Optometri
Publication and Content Type
- ref (subject category)
- art (subject category)
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