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Development of duck...
Development of duck hepatitis A virus type 3 vaccine and its use to protect ducklings against infections
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Kim, MC (author)
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Kim, M-J (author)
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Kwon, Y-K (author)
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- Lindberg, A. Michael (author)
- Högskolan i Kalmar,Naturvetenskapliga institutionen
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Joh, S-J (author)
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Kwon, H-M (author)
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Lee, Y-J (author)
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Kwon, J-H (author)
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
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In: Vaccine. - : Elsevier BV. - 0264-410X .- 1873-2518. ; 27:8, s. 6688-6694
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- A variant type of duck hepatitis A virus (DHAV), DHAV-3 was recently discovered in South Korea and China. Sequence analyses verified that the variant is genetically or serologically different from the DHAV-1 and DHAV-2 types. Duck hepatitis had been reported in South Korea since 1985 and an attenuated DHAV-1 vaccine had efficiently prevented epidemics of DHAV-1 until 2002. Despite the DHAV-1 based vaccine in use the novel DHAV-3 circulating in South Korea remains to be a threat to duckling farming. To develop a live attenuated vaccine against DHAV-3, a representative isolate, AP-04203, was therefore attenuated by repeated passages in SPF chicken embryos 100 times. The 100th passaged virus, AP-04203P100, did not cause clinical sign and mortality in 1-day-old ducklings as well as reversion of virulence capacity. The ducklings vaccinated with AP-04203P100 virus (10(3.0) ELD(50)/0.2 ml) on 1-day-old age via the intramuscular injection were well protected from 2 days after challenge with pathogenic AP04203P1 virus via the intramuscular route. In addition, the vaccine candidate also exhibited complete protection against currently circulating pathogenic DHAV-3 isolates. In conclusion, we demonstrate that the live attenuated virus, AP-04203P100, is a promising vaccine candidate facilitating the prevention of duck hepatitis caused by DHAV-3 around East Asia including South Korea.
Subject headings
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Keyword
- Virologi
- Virology
- Mikrobiologi
- Microbiology
- Biomedicinsk vetenskap
- Biomedical Sciences
Publication and Content Type
- ref (subject category)
- art (subject category)
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