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Compliance to Oseltamivir among Two Populations in Oxfordshire, United Kingdom Affected by Influenza A(H1N1)pdm09, November 2009 : A Waste Water Epidemiology Study

Singer, Andrew C. (author)
NERC – Centre for Ecology and Hydrology, United Kingdom
Järhult, Josef D (author)
Uppsala universitet,Infektionssjukdomar
Grabic, Roman (author)
Umeå universitet,Kemiska institutionen,University of South Bohemia in České Budějovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Vodnany, Czech Republic,Umeå University ; University of South Bohemia in České Budějovice, Czech Republic
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Khan, Ghazanfar Ali, 1973- (author)
Umeå universitet,Kemiska institutionen,Umeå University
Fedorova, Ganna (author)
Umeå universitet,Kemiska institutionen,University of South Bohemia in České Budějovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Vodnany, Czech Republic,Umeå University ; University of South Bohemia in České Budějovice, Czech Republic
Fick, Jerker (author)
Umeå universitet,Kemiska institutionen,Umeå University
Lindberg, Richard H. (author)
Umeå universitet,Kemiska institutionen,Umeå University
Bowes, Michael J. (author)
NERC – Centre for Ecology and Hydrology, United Kingdom
Olsen, Björn (author)
Uppsala universitet,Linnéuniversitetet,Institutionen för biologi och miljö (BOM),Uppsala University,Infektionssjukdomar
Söderström Lindström, Hanna (author)
Umeå universitet,Kemiska institutionen,Umeå University
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 (creator_code:org_t)
2013-04-15
2013
English.
In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:4
Related links:
https://doi.org/10.1...
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https://urn.kb.se/re...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Antiviral provision remains the focus of many pandemic preparedness plans, however, there is considerable uncertainty regarding antiviral compliance rates. Here we employ a waste water epidemiology approach to estimate oseltamivir (Tamiflu (R)) compliance. Oseltamivir carboxylate (oseltamivir's active metabolite) was recovered from two waste water treatment plant (WWTP) catchments within the United Kingdom at the peak of the autumnal wave of the 2009 Influenza A (H1N1)pdm09 pandemic. Predictions of oseltamivir consumption from detected levels were compared with two sources of national government statistics to derive compliance rates. Scenario and sensitivity analysis indicated between 3-4 and 120-154 people were using oseltamivir during the study period in the two WWTP catchments and a compliance rate between 45-60%. With approximately half the collected antivirals going unused, there is a clear need to alter public health messages to improve compliance. We argue that a near real-time understanding of drug compliance at the scale of the waste water treatment plant (hundreds to millions of people) can potentially help public health messages become more timely, targeted, and demographically sensitive, while potentially leading to less mis- and un-used antiviral, less wastage and ultimately a more robust and efficacious pandemic preparedness plan.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Samhällsfarmaci och klinisk farmaci (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Social and Clinical Pharmacy (hsv//eng)
NATURVETENSKAP  -- Kemi (hsv//swe)
NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)
NATURVETENSKAP  -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
NATURAL SCIENCES  -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)

Keyword

Virologi
Virology
Pharmacology
Farmakologi

Publication and Content Type

ref (subject category)
art (subject category)

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