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Use of Structural P...
Use of Structural Phylogenetic Networks for Classification of the Ferritin-like Superfamily
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- Lundin, Daniel, 1965- (author)
- Stockholms universitet,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,Institutionen för biokemi och biofysik,Stockholm University;KTH Royal Institute of Technology,Jarone Pinhassi
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- Poole, Anthony M. (author)
- University of Canterbury, New Zealand
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- Sjöberg, Britt-Marie (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm University
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- Högbom, Martin (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm University
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(creator_code:org_t)
- 2012
- 2012
- English.
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In: Journal of Biological Chemistry. - 0021-9258 .- 1083-351X. ; 287:24, s. 20565-20575
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Abstract
Subject headings
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- In the postgenomic era, bioinformatic analysis of sequence similarity is an immensely powerful tool to gain insight into evolution and protein function. Over long evolutionary distances, however, sequence-based methods fail as the similarities become too low for phylogenetic analysis. Macromolecular structure generally appears better conserved than sequence, but clear models for how structure evolves over time are lacking. The exponential growth of three-dimensional structural information may allow novel structure-based methods to drastically extend the evolutionary time scales amenable to phylogenetics and functional classification of proteins. To this end, we analyzed 80 structures from the functionally diverse ferritin-like superfamily. Using evolutionary networks, we demonstrate that structural comparisons can delineate and discover groups of proteins beyond the “twilight zone” where sequence similarity does not allow evolutionary analysis, suggesting that considerable and useful evolutionary signal is preserved in three-dimensional structures.
Subject headings
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Ferritin
- Functional Prediction
- Molecular Evolution
- Phylogenetics
- Protein Evolution
- Protein Structure
- Ribonucleotide Reductase
- Evolutionary Biology
- Evolutionsbiologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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