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Altered Cytokine and BDNF Levels in Autism Spectrum Disorder
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- Ricci, S. (author)
- Univ Roma La Sapienza, Italy
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- Businaro, R. (author)
- Sapienza Univ, Italy
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- Ippoliti, F. (author)
- Univ Roma La Sapienza, Italy
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- (creator_code:org_t)
- 2013-04-19
- 2013
- English.
- In: Neurotoxicity research. - : Springer. - 1029-8428 .- 1476-3524. ; 24:4, s. 491-501
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The contribution of neuroimmune functioning and brain-derived neurotrophic factor (BDNF) to functional dysregulation in autism spectrum disorder was assessed in 29 patients under treatment in two specialized centers of Basilicata (Chiaromonte and Matera), Southern Italy, through analysis of serum levels of cytokines and BDNF. Elevated levels of the pro-inflammatory cytokine, including interleukin-1, interleukin-6, interleukin-12, interleukin-23, tumor necrosis factor-alpha and BDNF were observed, regardless of age and gender. Comparisons were made with age-and gender-related healthy controls. The present findings reinforce current notions regarding immunoexcitotoxic mechanisms contributing to the pathophysiology of autistic disorder.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Keyword
- Autism
- Immune system
- Cytokines
- Handicap
- Immunoexcitotoxicity
- Psychology
- Psykologi
- Autism - Immune system - Cytokines - Handicap - Immunoexcitotoxicity
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Ricci, S.
- Businaro, R.
- Ippoliti, F.
- Lo Vasco, V. R.
- Massoni, F.
- Onofri, E.
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- Troili, G. M.
- Pontecorvi, V.
- Morelli, M.
- Rapp-Ricciardi, ...
- Archer, Trevor
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
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- SOCIAL SCIENCES
- SOCIAL SCIENCES
- and Psychology
- Articles in the publication
- Neurotoxicity re ...
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- Linnaeus University
- University of Gothenburg
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