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Acute heart failure...
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Orrem, Hilde LOslo University Hospital, Norway
(author)
Acute heart failure following myocardial infarction : complement activation correlates with the severity of heart failure in patients developing cardiogenic shock.
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-02-09
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John Wiley & Sons,2018
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LIBRIS-ID:oai:DiVA.org:lnu-73333
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https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-73333URI
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https://doi.org/10.1002/ehf2.12266DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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AIMS: Heart failure (HF) is an impending complication to myocardial infarction. We hypothesized that the degree of complement activation reflects severity of HF following acute myocardial infarction.METHODS AND RESULTS: The LEAF trial (LEvosimendan in Acute heart Failure following myocardial infarction) evaluating 61 patients developing HF within 48 h after percutaneous coronary intervention-treated ST-elevation myocardial infarction herein underwent a post hoc analysis. Blood samples were drawn from inclusion to Day 5 and at 42 day follow-up, and biomarkers were measured with enzyme immunoassays. Regional myocardial contractility was measured by echocardiography as wall motion score index (WMSI). The cardiogenic shock group (n = 9) was compared with the non-shock group (n = 52). Controls (n = 44) were age-matched and sex-matched healthy individuals. C4bc, C3bc, C3bBbP, and sC5b-9 were elevated in patients at inclusion compared with controls (P < 0.01). The shock group had higher levels compared with the non-shock group for all activation products except C3bBbP (P < 0.05). At Day 42, all products were higher in the shock group (P < 0.05). In the shock group, sC5b-9 correlated significantly with WMSI at baseline (r = 0.68; P = 0.045) and at Day 42 (r = 0.84; P = 0.036). Peak sC5b-9 level correlated strongly with WMSI at Day 42 (r = 0.98; P = 0.005). Circulating endothelial cell activation markers sICAM-1 and sVCAM-1 were higher in the shock group during the acute phase (P < 0.01), and their peak levels correlated with sC5b-9 peak level in the whole HF population (r = 0.32; P = 0.014 and r = 0.30; P = 0.022, respectively).CONCLUSIONS: Complement activation discriminated cardiogenic shock from non-shock in acute ST-elevation myocardial infarction complicated by HF and correlated with regional contractility and endothelial cell activation, suggesting a pathogenic role of complement in this condition.
Subject headings and genre
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Nilsson, Per H.,1980-Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),University of Oslo, Norway;Oslo University Hospital, Norway,Linnaeus Ctr Biomat Chem, BMC;HoRB(Swepub:lnu)enipe
(author)
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Pischke, Søren EOslo University Hospital, Norway
(author)
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Grindheim, GuroOslo University Hospital, Norway
(author)
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Garred, PeterUniversity of Copenhagen, Denmark
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Seljeflot, IngebjørgOslo University Hospital, Norway;University of Oslo, Norway
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Husebye, TrygveOslo University Hospital, Norway;University of Oslo, Norway
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Aukrust, PålUniversity of Oslo, Norway;Oslo University Hospital, Norway
(author)
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Yndestad, ArneUniversity of Oslo, Norway;Oslo University Hospital, Norway
(author)
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Andersen, Geir ØOslo University Hospital, Norway;University of Oslo, Norway
(author)
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Barratt-Due, AndreasOslo University Hospital, Norway
(author)
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Mollnes, Tom EOslo University Hospital, Norway;University of Oslo, Norway;University of Tromsø, Norway;Norwegian University of Science and Technology, Norway
(author)
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Oslo University Hospital, NorwayInstitutionen för kemi och biomedicin (KOB)
(creator_code:org_t)
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In:ESC Heart Failure: John Wiley & Sons5:3, s. 292-3012055-5822
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Orrem, Hilde L
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Nilsson, Per H., ...
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Pischke, Søren E
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Grindheim, Guro
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Garred, Peter
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Seljeflot, Ingeb ...
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Husebye, Trygve
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Aukrust, Pål
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Yndestad, Arne
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Andersen, Geir Ø
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Barratt-Due, And ...
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Mollnes, Tom E
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- MEDICAL AND HEALTH SCIENCES
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Linnaeus University