Search: onr:"swepub:oai:DiVA.org:lnu-73796" > Novel ATP-cone-driv...
Fältnamn | Indikatorer | Metadata |
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000 | 06626naa a2200673 4500 | |
001 | oai:DiVA.org:lnu-73796 | |
003 | SwePub | |
008 | 180503s2018 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-144937 | |
009 | oai:DiVA.org:su-153793 | |
009 | oai:DiVA.org:uu-345724 | |
009 | oai:lup.lub.lu.se:1996e8d2-e4b2-4d0b-9e29-99584aa843a1 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-737962 URI |
024 | 7 | a https://doi.org/10.7554/eLife.315292 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1449372 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1537932 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3457242 URI |
024 | 7 | a https://lup.lub.lu.se/record/1996e8d2-e4b2-4d0b-9e29-99584aa843a12 URI |
040 | a (SwePub)lnud (SwePub)umud (SwePub)sud (SwePub)uud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Rozman Grinberg, Innau Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Stockholm, Sweden.,Stockholm University4 aut0 (Swepub:su)rinna |
245 | 1 0 | a Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit |
264 | 1 | b ELIFE SCIENCES PUBLICATIONS LTD,c 2018 |
338 | a electronic2 rdacarrier | |
520 | a Ribonucleotide reductases (RNRs) are key enzymes in DNA metabolism, with allosteric mechanisms controlling substrate specificity and overall activity. In RNRs, the activity master-switch, the ATP-cone, has been found exclusively in the catalytic subunit. In two class I RNR subclasses whose catalytic subunit lacks the ATP-cone, we discovered ATP-cones in the radical-generating subunit. The ATP-cone in the Leeuwenhoekiella blandensis radical-generating subunit regulates activity via quaternary structure induced by binding of nucleotides. ATP induces enzymatically competent dimers, whereas dATP induces non-productive tetramers, resulting in different holoenzymes. The tetramer forms by interactions between ATP-cones, shown by a 2.45 A crystal structure. We also present evidence for an (MnMnIV)-Mn-III metal center. In summary, lack of an ATP-cone domain in the catalytic subunit was compensated by transfer of the domain to the radical-generating subunit. To our knowledge, this represents the first observation of transfer of an allosteric domain between components of the same enzyme complex. | |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
653 | a Biokemi | |
653 | a Biochemistry | |
700 | 1 | a Lundin, Daniel,d 1965-u Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Stockholm, Sweden.,Stockholm University4 aut0 (Swepub:su)dlund |
700 | 1 | a Hasan, Mahmudulu Stockholm University,Lunds universitet,Stockholms universitet,Institutionen för biokemi och biofysik,Lund University, Sweden,Stockholm Univ, Dept Biochem & Biophys, Stockholm, Sweden.;Lund Univ, Dept Biochem & Struct Biol, Lund, Sweden.,Stockholm University ; Lund University,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)med-mmh |
700 | 1 | a Crona, Mikaelu Swedish Ophan Biovitrum AB, Stockholm, Sweden.4 aut |
700 | 1 | a Rao Jonna, Venkateswarau Umeå universitet,Institutionen för medicinsk kemi och biofysik,Umea Univ, Dept Med Biochem & Biophys, Umea, Sweden.,Umeå University4 aut0 (Swepub:umu)vera0003 |
700 | 1 | a Loderer, Chrishtophu Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Stockholm, Sweden.,Stockholm University4 aut0 (Swepub:su)clode |
700 | 1 | a Sahlin, Margaretau Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Stockholm, Sweden.,Stockholm University4 aut0 (Swepub:su)msahl |
700 | 1 | a Markova, Nataliau Malvern Instruments Inc, Malvern, Sweden.4 aut0 (Swepub:lu)extLU-753 |
700 | 1 | a Borovok, Ilyau Tel Aviv University, Israel,Tel Aviv Univ, Dept Mol Microbiol & Biotechnol, Tel Aviv, Israel.4 aut |
700 | 1 | a Berggren, Gustavu Uppsala universitet,Molekylär biomimetik,Uppsala University4 aut0 (Swepub:uu)guber255 |
700 | 1 | a Hofer, Andersu Umeå universitet,Institutionen för medicinsk kemi och biofysik,Umea Univ, Dept Med Biochem & Biophys, Umea, Sweden.,Umeå University4 aut0 (Swepub:umu)anho0002 |
700 | 1 | a Logan, Derek T.u Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)mbfys-do |
700 | 1 | a Sjöberg, Britt-Marieu Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Stockholm, Sweden.,Stockholm University4 aut0 (Swepub:su)bsjob |
710 | 2 | a Stockholms universitetb Institutionen för biokemi och biofysik4 org |
773 | 0 | t eLIFEd : ELIFE SCIENCES PUBLICATIONS LTDg 7q 7x 2050-084X |
856 | 4 | u https://doi.org/10.7554/eLife.31529y Fulltext |
856 | 4 | u https://lnu.diva-portal.org/smash/get/diva2:1203595/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1185338/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1190210/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://dx.doi.org/10.7554/eLife.31529x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-73796 |
856 | 4 8 | u https://doi.org/10.7554/eLife.31529 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-144937 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-153793 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-345724 |
856 | 4 8 | u https://lup.lub.lu.se/record/1996e8d2-e4b2-4d0b-9e29-99584aa843a1 |
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