Search: onr:"swepub:oai:DiVA.org:lnu-77490" >
Characterization of...
Characterization of avian influenza virus attachment patterns to human and pig tissues
-
- Eriksson, Per (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
-
- Lindskog, Cecilia (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
-
- Engholm, Ebbe (author)
- Univ Copenhagen, Chem Biol, Dept Chem, DK-1871 Frederiksberg C, Denmark
-
show more...
-
- Blixt, Ola (author)
- Univ Copenhagen, Chem Biol, Dept Chem, DK-1871 Frederiksberg C, Denmark
-
- Waldenström, Jonas, 1975- (author)
- Linnéuniversitetet,Institutionen för biologi och miljö (BOM),Ctr Ecol & Evolut Microbial Model Syst EEMiS,Linnaeus Univ, Ctr Ecol & Evolut Microbial Model Syst, SE-39231 Kalmar, Sweden
-
- Munster, Vincent (author)
- NIAID, Lab Virol, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA
-
- Lundkvist, Åke (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
-
- Olsen, Björn (author)
- Uppsala University, Sweden,Uppsala Univ, Zoonosis Sci Ctr, Dept Med Sci, SE-75123 Uppsala, Sweden
-
- Jourdain, Elsa (author)
- INRA, EPIA, VetAgro Sup, UMR0346, FR-63122 St Genes Champanelle, France
-
- Ellström, Patrik (author)
- Uppsala University, Sweden,Uppsala Univ, Zoonosis Sci Ctr, Dept Med Sci, SE-75123 Uppsala, Sweden
-
show less...
-
(creator_code:org_t)
- 2018-08-15
- 2018
- English.
-
In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 8
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://www.nature.c...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Wild birds of Anseriformes and Charadriiformes are natural reservoirs of influenza A viruses (IAVs). Occasionally, IAVs transmit and adapt to mammalian hosts, and are maintained as epidemic strains in their new hosts. Viral adaptions to mammalian hosts include altered receptor preference of host epithelial sialylated oligosaccharides from terminal alpha 2,3-linked sialic acid (SA) towards alpha 2,6-linked SA. However, alpha 2,3-linked SA has been found in human respiratory tract epithelium, and human infections by avian IAVs (AIVs) have been reported. To further explore the attachment properties of AIVs, four AIVs of different subtypes were investigated on human and pig tissues using virus histochemistry. Additionally, glycan array analysis was performed for further characterization of IAVs' receptor structure tropism. Generally, AIV attachment was more abundant to human tissues than to pig tissues. The attachment pattern was very strong to human conjunctiva and upper respiratory tract, but variable to the lower respiratory tract. AIVs mainly attached to alpha 2,3-linked SA, but also to combinations of alpha 2,3-and alpha 2,6-linked SA. The low attachment of these AIV isolates to pig tissues, but high attachment to human tissues, addresses the question whether AIVs in general require passage through pigs to obtain adaptions towards mammalian receptor structures.
Subject headings
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Keyword
- Zoonotic Ecology
- Zoonotisk ekologi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Eriksson, Per
-
Lindskog, Cecili ...
-
Engholm, Ebbe
-
Blixt, Ola
-
Waldenström, Jon ...
-
Munster, Vincent
-
show more...
-
Lundkvist, Åke
-
Olsen, Björn
-
Jourdain, Elsa
-
Ellström, Patrik
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Microbiology
- Articles in the publication
-
Scientific Repor ...
- By the university
-
Linnaeus University
-
Uppsala University