Search: onr:"swepub:oai:DiVA.org:lnu-89544" >
Patient Characteris...
-
van der Ploeg, Milly A.Leiden Univ, Netherlands,Leiden University Medical Centre
(author)
Patient Characteristics and General Practitioners' Advice to Stop Statins in Oldest-Old Patients : a Survey Study Across 30 Countries
- Article/chapterEnglish2019
Publisher, publication year, extent ...
-
2019-01-16
-
Springer,2019
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:lnu-89544
-
https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-89544URI
-
https://doi.org/10.1007/s11606-018-4795-xDOI
-
https://lup.lub.lu.se/record/5e6fa70d-6c6d-4f2c-8276-e9c19d522416URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Background Statins are widely used to prevent cardiovascular disease (CVD). With advancing age, the risks of statins might outweigh the potential benefits. It is unclear which factors influence general practitioners' (GPs) advice to stop statins in oldest-old patients. Objective To investigate the influence of a history of CVD, statin-related side effects, frailty and short life expectancy, on GPs' advice to stop statins in oldest-old patients. Design We invited GPs to participate in this case-based survey. GPs were presented with 8 case vignettes describing patients > 80 years using a statin, and asked whether they would advise stopping statin treatment. Main Measures Cases varied in history of CVD, statin-related side effects and frailty, with and without shortened life expectancy (< 1 year) in the context of metastatic, non-curable cancer. Odds ratios adjusted for GP characteristics (ORadj) were calculated for GPs' advice to stop. Key Results Two thousand two hundred fifty GPs from 30 countries participated (median response rate 36%). Overall, GPs advised stopping statin treatment in 46% (95%CI 45-47) of the case vignettes; with shortened life expectancy, this proportion increased to 90% (95CI% 89-90). Advice to stop was more frequent in case vignettes without CVD compared to those with CVD (ORadj 13.8, 95%CI 12.6-15.1), with side effects compared to without ORadj 1.62 (95%CI 1.5-1.7) and with frailty (ORadj 4.1, 95%CI 3.8-4.4) compared to without. Shortened life expectancy increased advice to stop (ORadj 50.7, 95%CI 45.5-56.4) and was the strongest predictor for GP advice to stop, ranging across countries from 30% (95%CI 19-42) to 98% (95% CI 96-99). Conclusions The absence of CVD, the presence of statin-related side effects, and frailty were all independently associated with GPs' advice to stop statins in patients aged > 80 years. Overall, and within all countries, cancer-related short life expectancy was the strongest independent predictor of GPs' advice to stop statins.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Streit, SvenUniv Bern, Switzerland
(author)
-
Achterberg, Wilco P.Leiden Univ, Netherlands
(author)
-
Beers, ErnaUniv Amsterdam, Netherlands
(author)
-
Bohnen, Arthur M.Erasmus MC, Netherlands
(author)
-
Burman, Robert A.Vennesla Primary Hlth Care Ctr, Norway
(author)
-
Collins, ClaireIrish Coll Gen Practitioners, Ireland
(author)
-
Franco, Fabio G.Hosp Israelita Albert Einstein, Brazil
(author)
-
Gerasimovska-Kitanovska, BiljanaUniv St Cyril & Metodius, Macedonia
(author)
-
Gintere, SandraRiga Stradins Univ, Latvia
(author)
-
Bravo, Raquel GomezUniv Luxembourg, Luxembourg
(author)
-
Hoffmann, KathrynMed Univ Vienna, Austria
(author)
-
Iftode, ClaudiaTimis Soc Family Med, Romania
(author)
-
Pestic, Sanda KreitmayerUniv Tuzla, Bosnia and Herzegovina
(author)
-
Koskela, Tuomas H.Univ Tampere, Finland
(author)
-
Kurpas, DonataWroclaw Med Univ, Poland
(author)
-
Maisonneuve, HubertUniv Geneva, Switzerland
(author)
-
Mallen, Christan D.Keele Univ, UK
(author)
-
Merlo, ChristophInst Primary & Community Care Lucerne IHAM, Switzerland
(author)
-
Mueller, YolandaInst Family Med Lausanne IUMF, Switzerland
(author)
-
Muth, ChristianeGoethe Univ, Germany
(author)
-
Petrazzuoli, FerdinandoLund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups,National Society of Medical Education in General Practice (SNAMID)(Swepub:lu)med-fpz
(author)
-
Rodondi, NicolasUniv Bern, Switzerland
(author)
-
Rosemann, ThomasUniv Zurich, Switzerland
(author)
-
Sattler, MartinSSLMG, Luxembourg
(author)
-
Schermer, TjardRadboud Univ Nijmegen, Netherlands
(author)
-
Ster, Marija PetekUniv Ljubljana, Slovenia
(author)
-
Svadlenkova, ZuzanaOrdinace Repy Sro, Czech Republic
(author)
-
Tatsioni, AthinaUniv Ioannina, Greece
(author)
-
Thulesius, HansLund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups,Region Kronoberg(Swepub:lu)smi-hth
(author)
-
Tkachenko, VictoriaShupyk Natl Med Acad Postgrad Educ, Ukraine
(author)
-
Torzsa, PeterSemmelweis Univ, Hungary
(author)
-
Tsopra, RosyUniv Paris 13, France
(author)
-
Tuz, CananErzincan Univ, Turkey
(author)
-
Vaes, BertUniv Leuven KU Leuven, Belgium
(author)
-
Viegas, Rita P. A.NOVA Med Sch, Portugal
(author)
-
Vinker, ShlomoTel Aviv Univ, Israel
(author)
-
Wallis, Katharine A.Univ Auckland, New Zealand
(author)
-
Zeller, AndreasUniv Basel, Switzerland
(author)
-
Gussekloo, JacobijnLeiden Univ, Netherlands
(author)
-
Poortvliet, Rosalinde K. E.Leiden Univ, Netherlands,Leiden University Medical Centre
(author)
-
Leiden Univ, NetherlandsLeiden University Medical Centre
(creator_code:org_t)
-
et al.
Related titles
-
In:Journal of general internal medicine: Springer34:9, s. 1751-17570884-87341525-1497
Internet link
Find in a library
To the university's database
- By the author/editor
-
van der Ploeg, M ...
-
Streit, Sven
-
Achterberg, Wilc ...
-
Beers, Erna
-
Bohnen, Arthur M ...
-
Burman, Robert A ...
-
show more...
-
Collins, Claire
-
Franco, Fabio G.
-
Gerasimovska-Kit ...
-
Gintere, Sandra
-
Bravo, Raquel Go ...
-
Hoffmann, Kathry ...
-
Iftode, Claudia
-
Pestic, Sanda Kr ...
-
Koskela, Tuomas ...
-
Kurpas, Donata
-
Maisonneuve, Hub ...
-
Mallen, Christan ...
-
Merlo, Christoph
-
Mueller, Yolanda
-
Muth, Christiane
-
Petrazzuoli, Fer ...
-
Rodondi, Nicolas
-
Rosemann, Thomas
-
Sattler, Martin
-
Schermer, Tjard
-
Ster, Marija Pet ...
-
Svadlenkova, Zuz ...
-
Tatsioni, Athina
-
Thulesius, Hans
-
Tkachenko, Victo ...
-
Torzsa, Peter
-
Tsopra, Rosy
-
Tuz, Canan
-
Vaes, Bert
-
Viegas, Rita P. ...
-
Vinker, Shlomo
-
Wallis, Katharin ...
-
Zeller, Andreas
-
Gussekloo, Jacob ...
-
Poortvliet, Rosa ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Geriatrics
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and General Practice
- Articles in the publication
-
Journal of gener ...
- By the university
-
Linnaeus University
-
Lund University