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Search: onr:"swepub:oai:DiVA.org:ltu-102318" > Antioxidant enzymes...

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  • Galvan-Alvarez, VictorDepartment of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain (author)

Antioxidant enzymes and Nrf2/Keap1 in human skeletal muscle: Influence of age, sex, adiposity and aerobic fitness

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Elsevier Inc.2023
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:ltu-102318
  • https://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-102318URI
  • https://doi.org/10.1016/j.freeradbiomed.2023.10.393DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Validerad;2023;Nivå 2;2023-11-13 (joosat);Funder: Consejo Superior de Deportes (EXP_75097); Swedish Olympic Committee (070–4058960); Ministerio de Economía y Competitividad (DEP2015-71171-R, DEP2017-86409-C2-1-P, PI14/01509, PID2021-125354OB-C21); University of Las Palmas de Gran Canaria (ULPAPD-08/01–4); Agencia Canaria de Investigación, Innovación y Sociedad de la Infomación (ProID2017010106); Cabildo de Gran Canaria (12/22);License fulltext: CC BY
  • Whether a higher aerobic fitness is associated with increased expression of antioxidant enzymes and their regulatory factors in skeletal muscle remains unknown. Although oestrogens could promote a higher antioxidant capacity in females, it remains unknown whether a sex dimorphism exists in humans regarding the antioxidant capacity of skeletal muscle. Thus, the aim was to determine the protein expression levels of the antioxidant enzymes SOD1, SOD2, catalase and glutathione reductase (GR) and their regulatory factors Nrf2 and Keap1 in 189 volunteers (120 males and 69 females) to establish whether sex differences exist and how age, VO2max and adiposity influence these. For this purpose, vastus lateralis muscle biopsies were obtained in all participants under resting and unstressed conditions. No significant sex differences in Nrf2, Keap1, SOD1, SOD2, catalase and GR protein expression levels were observed after accounting for VO2max, age and adiposity differences. Multiple regression analysis indicates that the VO2max in mL.kg LLM−1.min−1can be predicted from the levels of SOD2, Total Nrf2 and Keap1 (R = 0.58, P < 0.001), with SOD2 being the main predictor explaining 28 % of variance in VO2max, while Nrf2 and Keap1 explained each around 3 % of the variance. SOD1 protein expression increased with ageing in the whole group after accounting for differences in VO2max and body fat percentage. Overweight and obesity were associated with increased pSer40-Nrf2, pSer40-Nrf2/Total Nrf2 ratio and SOD1 protein expression levels after accounting for differences in age and VO2max. Overall, at the population level, higher aerobic fitness is associated with increased basal expression of muscle antioxidant enzymes, which may explain some of the benefits of regular exercise.

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  • Gallego-Selles, AngelDepartment of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain (author)
  • Martinez-Canton, MiriamDepartment of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain (author)
  • García-Gonzalez, EduardoDepartment of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain (author)
  • Gelabert-Rebato, MiriamDepartment of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain (author)
  • Ponce-Gonzalez, Jesus GustavoDepartment of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain (author)
  • Larsen, SteenCenter of Healthy Ageing, Department of Biomedical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark; Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland (author)
  • Morales-Alamo, DavidDepartment of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain (author)
  • Losa-Reyna, JoseDepartment of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain (author)
  • Perez-Suarez, IsmaelDepartment of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain (author)
  • Dorado, CeciliaDepartment of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain (author)
  • Perez-Valera, MarioDepartment of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain (author)
  • Holmberg, Hans-ChristerLuleå tekniska universitet,Hälsa, medicin och rehabilitering,School of Kinesiology, Faculty of Education, The University of British Columbia, Vancouver, BC, Canada(Swepub:ltu)holhan (author)
  • Boushel, RobertSchool of Kinesiology, Faculty of Education, The University of British Columbia, Vancouver, BC, Canada (author)
  • de Pablos Velasco, PedroResearch Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain; Department of Endocrinology and Nutrition, Hospital Universitario de Gran Canaria Doctor Negrin, Las Palmas de Gran Canaria, Spain (author)
  • Helge, Jorn WulffCenter of Healthy Ageing, Department of Biomedical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark (author)
  • Martin-Rincon, MarcosDepartment of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain (author)
  • Calbet, Jose A.L.Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain; School of Kinesiology, Faculty of Education, The University of British Columbia, Vancouver, BC, Canada; Department of Physical Performance, The Norwegian School of Sport Sciences, Postboks, 4014 Ulleval Stadion, 0806, Oslo, Norway (author)
  • Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, SpainDepartment of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain (creator_code:org_t)

Related titles

  • In:Free Radical Biology & Medicine: Elsevier Inc.209:Part 2, s. 282-2910891-58491873-4596

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