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Origin of Deteriora...
Origin of Deteriorated Crystal Plasticity and Compaction Properties of a 1:1 Cocrystal between Piroxicam and Saccharin
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- Chattoraj, Sayantan (author)
- Pharmaceutical Materials Science & Engineering Laboratory, Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota 55455, United States
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- Shi, Limin (author)
- Pharmaceutical Materials Science & Engineering Laboratory, Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota 55455, United States
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- Chen, Miles (author)
- Pharmaceutical Materials Science & Engineering Laboratory, Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota 55455, United States
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- Alhalaweh, Amjad (author)
- Luleå tekniska universitet,Medicinsk vetenskap
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- Velaga, Sitaram (author)
- Luleå tekniska universitet,Medicinsk vetenskap
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- Sun, Changquan Calvin (author)
- Pharmaceutical Materials Science & Engineering Laboratory, Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota 55455, United States
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(creator_code:org_t)
- 2014-06-25
- 2014
- English.
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In: Crystal Growth & Design. - : American Chemical Society (ACS). - 1528-7483 .- 1528-7505. ; 14:8, s. 3864-3874
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The 1:1 cocrystal between piroxicam and saccharin exhibits significantly deteriorated powder compaction properties compared to both coformers. The molecular origin of this effect is revealed by a systematic investigation of crystal mechanical properties, probed with nanoindentation, and crystal structure analysis. The order of bulk powder tabletability of the three materials is identical to that of single crystal plasticity (saccharin > piroxicam > cocrystal). The lowest plasticity of the cocrystal is confirmed by its highest crystal hardness and the highest yield strength. The low plasticity of the cocrystal is attributed to structural packing features that discourage plastic deformation. This work demonstrates that cocrystallization, even though it may be useful to improve pharmaceutically relevant properties, must be carefully evaluated to avoid unexpected problems in formulation and drug product manufacturing due to compromised mechanical properties.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Annan hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Other Health Sciences (hsv//eng)
Keyword
- Health Science
- Hälsovetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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