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Theophylline cocrys...
Theophylline cocrystals prepared by spray drying : physicochemical properties and aerosolization performance
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- Alhalaweh, Amjad (author)
- Luleå tekniska universitet,Medicinsk vetenskap
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- Kaialy, Waseem (author)
- Luleå tekniska universitet,Medicinsk vetenskap
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- Buckton, Graham (author)
- Department of Pharmaceutics, School of Pharmacy, University College London
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- Gill, Hardyal (author)
- Chemistry and Drug Delivery Group, Medway School of Pharmacy, University of Kent
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- Nokhodchi, Ali (author)
- Chemistry and Drug Delivery Group, Medway School of Pharmacy, University of Kent
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- Velaga, Sitaram (author)
- Luleå tekniska universitet,Medicinsk vetenskap
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(creator_code:org_t)
- 2013-01-08
- 2013
- English.
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In: AAPS PharmSciTech. - : Springer Science and Business Media LLC. - 1530-9932. ; 14:1, s. 265-276
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The purpose of this work was to characterize theophylline (THF) cocrystals prepared by spray drying in terms of the physicochemical properties and inhalation performance when aerosolized from a dry powder inhaler. Cocrystals of theophylline with urea (THF-URE), saccharin (THF-SAC) and nicotinamide (THF-NIC) were prepared by spray drying. Milled THF and THF-SAC cocrystals were also used for comparison. The physical purity, particle size, particle morphology and surface energy of the materials were determined. The in vitro aerosol performance of the spray-dried cocrystals, drug-alone and a drug-carrier aerosol, was assessed. The spray-dried particles had different size distributions, morphologies and surface energies. The milled samples had higher surface energy than those prepared by spray drying. Good agreement was observed between multi-stage liquid impinger and next-generation impactor in terms of assessing spray-dried THF particles. The fine particle fractions of both formulations were similar for THF, but drug-alone formulations outperformed drug-carrier formulations for the THF cocrystals. The aerosolization performance of different THF cocrystals was within the following rank order as obtained from both drug-alone and drug-carrier formulations: THF-NIC > THF-URE > THF-SAC. It was proposed that micromeritic properties dominate over particle surface energy in terms of determining the aerosol performance of THF cocrystals. Spray drying could be a potential technique for preparing cocrystals with modified physical properties.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Annan hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Other Health Sciences (hsv//eng)
Keyword
- Health Science
- Hälsovetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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