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Amyloid Hydrogen Bo...
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Wei, JuanDepartment of Chemistry and Department of Physics, University of Warwick, Coventry
(author)
Amyloid Hydrogen Bonding Polymorphism Evaluated by 15N{17O}REAPDOR Solid-State NMR and Ultra-High Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-04-01
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American Chemical Society (ACS),2016
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:ltu-3009
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https://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-3009URI
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https://doi.org/10.1021/acs.biochem.5b01095DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Validerad; 2016; Nivå 2; 20160414 (andbra)
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A combined approach, using Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) and solid-state NMR (Nuclear Magnetic Resonance), shows a high degree of polymorphism exhibited by Aβ species in forming hydrogen-bonded networks. Two Alzheimer’s Aβ peptides, Ac-Aβ16–22-NH2 and Aβ11–25, selectively labeled with 17O and 15N at specific amino acid residues were investigated. The total amount of peptides labeled with 17O as measured by FTICR-MS enabled the interpretation of dephasing observed in 15N{17O}REAPDOR solid-state NMR experiments. Specifically, about one-third of the Aβ peptides were found to be involved in the formation of a specific >C═17O···H–15N hydrogen bond with their neighbor peptide molecules, and we hypothesize that the rest of the molecules undergo ± n off-registry shifts in their hydrogen bonding networks.
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Antzutkin, OlegLuleå tekniska universitet,Kemiteknik(Swepub:ltu)olan
(author)
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Filippov, AndreiLuleå tekniska universitet,Kemiteknik(Swepub:ltu)andfil
(author)
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Iuga, DinuDepartment of Physics, Warwick University, Coventry, Department of Chemistry and Department of Physics, University of Warwick, Coventry
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Lam, Pui YiuDepartment of Chemistry and Department of Physics, University of Warwick, Coventry
(author)
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Barrow, Mark P.Department of Chemistry and Department of Physics, University of Warwick, Coventry
(author)
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Dupree, RayUniversity of Warwick, Department of Physics, Warwick University, Coventry, Department of Chemistry and Department of Physics, University of Warwick, Coventry
(author)
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Brown, Steven P.Department of Physics, Warwick University, Coventry, Department of Chemistry and Department of Physics, University of Warwick, Coventry
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O'Connor, Peter B.Department of Chemistry and Department of Physics, University of Warwick, Coventry
(author)
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Department of Chemistry and Department of Physics, University of Warwick, CoventryKemiteknik
(creator_code:org_t)
Related titles
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In:Biochemistry: American Chemical Society (ACS)55:14, s. 2065-20680006-29601520-4995
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