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Monohydrous dihydro...
Monohydrous dihydrogen phosphate salts of norfloxacin and ciprofloxacin
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- Lou, Benyong (author)
- Luleå tekniska universitet,Medicinsk vetenskap
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- Boström, Dan (author)
- Energy Technology and Thermal Process Chemistry, Umeå University
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- Velaga, Sitaram (author)
- Luleå tekniska universitet,Medicinsk vetenskap
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(creator_code:org_t)
- 2007
- 2007
- English.
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In: Acta Crystallographica Section C. - 0108-2701 .- 1600-5759. ; 63:12, s. 731-733
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Norfloxacin and ciprofloxacin crystallize with phosphoric acid in aqueous solution to give the salts 4-(3-carboxy-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-7-quinolyl)piperazinium dihydrogenphosphate monohydrate, C16H19FN3O3(+) x H2PO4(-) x H2O, and 4-(3-carboxy-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-7-quinolyl)piperazinium dihydrogenphosphate monohydrate, C17H19FN3O3(+) x H2PO4(-) x H2O, respectively. In the crystal structures, the phosphate anions and the piperazine rings of norfloxacin or ciprofloxacin form a 12-membered supramolecular synthon, viz. R4(4)(12). The synthons R4(4)(12) and R2(2)(8) formed between adjacent phosphate anions result in the three-dimensional structures.
Publication and Content Type
- ref (subject category)
- art (subject category)
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