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Dry powder inhalers :
Dry powder inhalers : An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products
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- Velaga, Sitaram (author)
- Luleå tekniska universitet,Medicinsk vetenskap
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- Djuris, Jelena (author)
- Department of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy
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- Cvijic, Sandra (author)
- Department of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy
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- Rozou, Stavroula (author)
- Elpen Pharmaceutical Co.
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- Russo, Paola (author)
- Department of Pharmacy, University of Salerno
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- Colombo, Gaia (author)
- Department of Life Sciences and Biotechnology, University of Ferrara
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- Rossi, Alessandra (author)
- Food and Drug Department, University of Parma
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(creator_code:org_t)
- Elsevier, 2018
- 2018
- English.
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In: European Journal of Pharmaceutical Sciences. - : Elsevier. - 0928-0987 .- 1879-0720. ; 113, s. 18-28
- Related links:
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https://iris.unife.i...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In vitro dissolution testing is routinely used in the development of pharmaceutical products. Whilst the dissolution testing methods are well established and standardized for oral dosage forms, i.e. tablets and capsules, there are no pharmacopoeia methods or regulatory requirements for testing the dissolution of orally inhaled powders. Despite this, a wide variety of dissolution testing methods for orally inhaled powders has been developed and their bio-relevance has been evaluated.The review provides an overview of the in vitro dissolution methodologies for dry inhalation products, with particular emphasis on dry powder inhaler, where the dissolution behavior of the respirable particles can have a role on duration and absorption of the drug. Dissolution mechanisms of respirable particles as well as kinetic models have been presented. A more recent bio-relevant dissolution set-ups and media for studying inhalation biopharmaceutics were also reviewed. In addition, factors affecting interplay between dissolution and absorption of deposited particles in the context of biopharmaceutical considerations of inhalation products were examined.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Annan hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Other Health Sciences (hsv//eng)
Keyword
- Health Science
- Hälsovetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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