Clinical outcome of adult onset asthma in a 15 year follow-up

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Almqvist, LinnéaUmeå universitet,Avdelningen för hållbar hälsa,Public health and clinical medicine, Sustainable helath, the OLIN unit, Umeå University, Umeå, Sweden (author)

Clinical outcome of adult onset asthma in a 15 year follow-up

Article/chapterEnglish2020

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2020-10-28
European Respiratory Society (ERS),2020
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LIBRIS-ID:oai:DiVA.org:ltu-82894
https://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-82894URI
https://doi.org/10.1183/13993003.congress-2020.1396DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180183URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Godkänd;2021;Nivå 0;2021-02-11 (alebob)
Supplement: 64Meeting Abstract: 1396
Background: Adult onset asthma is poorly studied and there are few long-term clinical follow-up studies.Aim: To study clinical characteristics of adult onset asthma in a 15-year follow-up.Method: Within the Obstructive Lung Disease in Northern Sweden (OLIN) studies, a cohort of n=309 subjects with adult onset asthma (aged 20-60 years) was recruited during 1995-99. The cohort was followed up in 2012-14 (n=205). Structured interviews and clinical examinations including spirometry were performed at both recruitment and follow-up. Skin prick tests were performed at recruitment and blood samples for cell counts and IgE at the follow-up. Asthma control was classified according to GINA 2006.Results: At follow-up n=182 (89%) still had asthma, while n=23 (11%) were in remission. Among individuals with persistent asthma, mean pre-bronchodilator FEV1 percent of predicted was 89.0 at follow-up, similar as recruitment 88.3. At recruitment 16.5% were smokers, and of these, 86.7% had quit smoking at follow-up. At follow-up, 39% had blood neutrophils ≥4.0x109/L, 23% had blood eosinophils ≥0.3x109/L, and 28% had specific IgE>0.35 IU/ml to any airborne allergen. Any respiratory symptoms were reported by 90% and 31% used medium or high dose inhaled corticosteroids (ICS), 20% low dose ICS whereas 20% had no treatment. 55% had controlled asthma, 32% partly controlled and 13% uncontrolled asthma.Conclusion: In this 15-year follow-up of adult onset asthma, the majority had persistent asthma. Smoking and high proportion using ICS may contribute to the stable lung function. Still, it should be noted that merely around every other had well controlled asthma.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Omvårdnad hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Nursing hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
Nursing
Omvårdnad
Asthma

Added entries (persons, corporate bodies, meetings, titles ...)

Backman, HelenaUmeå universitet,Avdelningen för hållbar hälsa,Public health and clinical medicine, Sustainable helath, the OLIN unit, Umeå University, Umeå, Sweden(Swepub:umu)heaban01 (author)
Stridsman, CarolineUmeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Division of Medicine, The OLIN Unit, Umeå University, Umeå, Sweden(Swepub:umu)cast0052 (author)
Lindberg, AnneUmeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Division of Medicine, The OLIN Unit, Umeå University, Umeå, Sweden(Swepub:umu)anelig02 (author)
Lundbäck, BoKrefting Research centre, Department of Internal Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden (author)
Rönmark, EvaUmeå universitet,Avdelningen för hållbar hälsa,Public health and clinical medicine, Sustainable helath, the OLIN unit, Umeå University, Umeå, Sweden(Swepub:umu)evra0004 (author)
Hedman, Linnea,1979-Umeå universitet,Luleå tekniska universitet,Omvårdnad och medicinsk teknik,Public health and clinical medicine, Sustainable helath, the OLIN unit, Umeå University,Avdelningen för hållbar hälsa,Department of Health Sciences, Luleå University of Technology, Luleå, Umeå, Sweden(Swepub:umu)evli0029 (author)
Umeå universitetAvdelningen för hållbar hälsa (creator_code:org_t)

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In:European Respiratory Journal: European Respiratory Society (ERS)56:Suppl 640903-19361399-3003

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