Search: onr:"swepub:oai:DiVA.org:ltu-87167" >
Genome-wide associa...
Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate
-
- Karlsson Sundbaum, Johanna (author)
- Uppsala universitet,Luleå tekniska universitet,Hälsa, medicin och rehabilitering,Department of Medical Sciences, Rheumatology, Uppsala University, SE-751 85, Uppsala, Sweden,Reumatologi,Department of Health Sciences, Luleå University of Technology, SE-971 87, Luleå, Sweden
-
- Baecklund, Eva, 1956- (author)
- Uppsala universitet,Reumatologi
-
- Eriksson, Niclas, 1978- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab
-
show more...
-
- Kohnke, Hugo (author)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab
-
- Wallenberg, Matilda (author)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab,Svensk Dos AB, Box 2, SE-751 03, Uppsala, Sweden
-
- Cavalli, Marco (author)
- Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab
-
- Wadelius, Claes, 1955- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,Wadelius
-
- Wadelius, Mia (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk farmakogenomik och osteoporos
-
- Hallberg, Pär, 1974- (author)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab
-
show less...
-
(creator_code:org_t)
- Future Medicine Ltd, 2021
- 2021
- English.
-
In: Pharmacogenomics (London). - : Future Medicine Ltd. - 1462-2416 .- 1744-8042. ; 22:15, s. 973-982
- Related links:
-
https://doi.org/10.2...
-
show more...
-
https://doi.org/10.2...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.2...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Aim: To identify novel genetic variants predisposing to elevation of Alanine aminotransferase (ALT) in rheumatoid arthritis (RA) patients after initiation of methotrexate (MTX) treatment. Patients & methods: We performed genome-wide association studies in 198 RA patients starting MTX. Outcomes were maximum level of ALT and ALT >1.5-times the upper level of normal within the first 6 months of treatment. Results: RAVER2 (rs72675408) was significantly associated with maximum level of ALT (p = 4.36 × 10-8). This variant is in linkage disequilibrium with rs72675451, which is associated with differential expression of JAK1 and RAVER2. Conclusion: We found an association between ALT elevation and genetic variants that may regulate the expression of JAK1 and RAVER2. JAK1 encodes a janus kinase involved in the pathogenesis of RA.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- cohort study
- genome-wide association studies
- hepatotoxicity
- methotrexate
- rheumatoid arthritis
- risk 13 factors
- Medicinsk vetenskap
- Medical Science
- Clinical Pharmacology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Karlsson Sundbau ...
-
Baecklund, Eva, ...
-
Eriksson, Niclas ...
-
Kohnke, Hugo
-
Wallenberg, Mati ...
-
Cavalli, Marco
-
show more...
-
Wadelius, Claes, ...
-
Wadelius, Mia
-
Hallberg, Pär, 1 ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Rheumatology and ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Clinical Laborat ...
- Articles in the publication
-
Pharmacogenomics ...
- By the university
-
Luleå University of Technology
-
Uppsala University