Sökning: onr:"swepub:oai:DiVA.org:ltu-8745" >
New cocrystals of e...
New cocrystals of ezetimibe with l-proline and imidazole
-
- Shimpi, Manishkumar (författare)
- Luleå tekniska universitet,Institutionen för hälsovetenskap
-
- Childs, Scott L. (författare)
- Renovo Research, Atlanta, GA
-
- Boström, Dan (författare)
- Umeå universitet,Institutionen för tillämpad fysik och elektronik,Umeå universitet, Energy Technology and Thermal Process Chemistry, Umeå University
-
visa fler...
-
- Velaga, Sitaram (författare)
- Luleå tekniska universitet,Medicinsk vetenskap
-
visa färre...
-
(creator_code:org_t)
- 2014
- 2014
- Engelska.
-
Ingår i: CrystEngComm. - : Royal Society of Chemistry (RSC). - 1466-8033. ; 16:38, s. 8984-8993
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- The objectives of the study were to screen and prepare cocrystals of anti-cholesterol drug ezetimibe (EZT) with the aim of increasing its solubility and dissolution rate. Thermodynamic phase diagram based high throughput screening was performed using wet milling/grinding or solution crystallization methods. A large number of coformers were tested and the resulting solids were preliminarily characterized using X-ray powder diffraction (PXRD) and Raman spectroscopy. Potential cocrystals of EZT with l-proline and imidazole and a solvate formamide were identified in the screening experiments. The cocrystal hits were further characterized by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), solution Proton nuclear magnetic resonance spectroscopy (1H-NMR) and single crystal XRD. The dissolution properties and stability of cocrystals were determined. Single-crystal X-ray diffraction data were obtained for EZT, EZT-IMI cocrystal and formamide solvate of ezetimibe. All three systems were crystallized in non-centrosymmetric orthorhombic space group P212121with Z = 4. Robust O-H⋯O, O-H⋯N, N-H⋯O and C-H⋯O hydrogen bonds played an important role in all these crystal structures. EZT-PRO cocrystal showed improved apparent solubility and solid state stability
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Annan hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Other Health Sciences (hsv//eng)
Nyckelord
- Health Science
- Hälsovetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas