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The effect of adher...
The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)
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- Ngandu, Tiia (author)
- Karolinska Institutet
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- Lehtisalo, Jenni (author)
- Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland
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- Korkki, Saana (author)
- Karolinska Institutet
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- Solomon, Alina (author)
- Karolinska Institutet
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- Coley, Nicola (author)
- Faculté de Médecine, INSERM-University of Toulouse UMR1295 (CERPOP), Toulouse, France; Department of Epidemiology and Public Health, Toulouse University Hospital, Toulouse, France,University Toulouse, FRA; Toulouse University Hospital, FRA
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- Antikainen, Riitta (author)
- Center for Life Course Health Research, University of Oulu, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland
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- Bäckman, Lars (author)
- Karolinska Institutet
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- Hänninen, Tuomo (author)
- Neurocenter, Department of Neurology, Kuopio University Hospital, Kuopio, Finland,Kuopio University Hospital, FIN
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- Lindström, Jaana (author)
- Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland
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- Laatikainen, Tiina (author)
- Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Joint municipal authority for North Karelia social and health services (Siun sote), Joensuu, Finland,Finnish Institute of Heallth & Welfare, FIN; University Eastern Finland, FIN; Joint Municipal Author North Karelia Social & Health, FIN
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- Paajanen, Teemu (author)
- Finnish Institute of Occupational Health, Helsinki, Finland,Finnish Institute of Occupational Health, FIN
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- Havulinna, Satu (author)
- Department of Public Health and Welfare, Functioning and Service Needs Unit, Finnish Institute for Health and Welfare, Helsinki, Finland
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- Peltonen, Markku (author)
- Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Stockholm, Sweden
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- Stigsdotter Neely, Anna, 1961- (author)
- Karlstads universitet,Luleå tekniska universitet,Hälsa, medicin och rehabilitering,Department of Social Psychological Sciences, Karlstad University, Karlstad, Sweden,Institutionen för sociala och psykologiska studier (from 2013),Luleå universitet
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- Strandberg, Timo (author)
- Center for Life Course Health Research, University of Oulu, Oulu, Finland; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
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- Tuomilehto, Jaakko (author)
- Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland; Department of Public Health, University of Helsinki, Helsinki, Finland; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia; South Ostrobothnia Central Hospital, Seinäjoki, Finland
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- Soininen, Hilkka (author)
- Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland; Neurocenter, Department of Neurology, Kuopio University Hospital, Kuopio, Finland,University Eastern Finland, FIN; Kuopio University Hospital, FIN
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- Kivipelto, Miia (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-10-20
- 2022
- English.
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In: Alzheimer's & Dementia. - : John Wiley & Sons. - 1552-5260 .- 1552-5279. ; 18:7, s. 1325-1334
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Abstract
Subject headings
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- Introduction: Lifestyle interventions may prevent cognitive decline, but the sufficient dose of intervention activities and lifestyle changes is unknown. We investigated how intervention adherence affects cognition in the FINGER trial (pre-specified subgroup analyses).Methods: FINGER is a multicenter randomized controlled trial examining the efficacy of multidomain lifestyle intervention (ClinicalTrials.gov NCT01041989). A total of 1260 participants aged 60 to 77 with increased dementia risk were randomized to a lifestyle intervention and control groups. Percentage of completed intervention sessions, and change in multidomain lifestyle score (self-reported diet; physical, cognitive, and social activity; vascular risk) were examined in relation to change in Neuropsychological Test Battery (NTB) scores.Results: Active participation was associated with better trajectories in NTB total and all cognitive subdomains. Improvement in lifestyle was associated with improvement in NTB total and executive function.Discussion: Multidomain lifestyle changes are beneficial for cognitive functioning, but future interventions should be intensive enough, and supporting adherence is essential.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- cognition
- lifestyle
- multidomain
- prevention
- Teknisk psykologi
- Engineering Psychology
- Psykologi inr. medicinsk psykologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ngandu, Tiia
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Lehtisalo, Jenni
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Korkki, Saana
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Solomon, Alina
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Coley, Nicola
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Antikainen, Riit ...
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show more...
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Bäckman, Lars
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Hänninen, Tuomo
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Lindström, Jaana
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Laatikainen, Tii ...
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Paajanen, Teemu
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Havulinna, Satu
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Peltonen, Markku
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Stigsdotter Neel ...
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Strandberg, Timo
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Tuomilehto, Jaak ...
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Soininen, Hilkka
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Kivipelto, Miia
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
- Articles in the publication
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Alzheimer's & De ...
- By the university
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Luleå University of Technology
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Karlstad University
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Karolinska Institutet