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Biodegradable magnesium-based implants in bone studied by synchrotron radiation microtomography

Moosmann, Julian (author)
Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, Geesthacht, D-21502, Germany
Zeller-Plumhoff, Berit (author)
Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, Geesthacht, D-21502, Germany
Wieland, D. C. Florian (author)
Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, Geesthacht, D-21502, Germany
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Galli, Silvia (author)
Malmö University,Malmö högskola,Odontologiska fakulteten (OD)
Krüger, Diana (author)
Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, Geesthacht, D-21502, Germany
Dose, Thomas (author)
Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, Geesthacht, D-21502, Germany
Burmester, Hilmar (author)
Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, Geesthacht, D-21502, Germany
Wilde, Fabian (author)
Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, Geesthacht, D-21502, Germany
Bech, Martin (author)
Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,X-ray Phase Contrast,Forskargrupper vid Lunds universitet,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
Peruzzi, Niccolò (author)
Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
Wiese, Björn (author)
Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, Geesthacht, D-21502, Germany
Hipp, Alexander (author)
Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, Geesthacht, D-21502, Germany
Beckmann, Felix (author)
Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, Geesthacht, D-21502, Germany
Hammel, Jörg (author)
Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, Geesthacht, D-21502, Germany
Willumeit-Römer, Regine (author)
Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, Geesthacht, D-21502, Germany; Institute of Materials Science, Christian-Albrechts-Universität zu Kiel, Christian-Albrechts-Platz 4, Kiel, D-24118, Germany
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Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str 1, Geesthacht, D-21502, Germany Odontologiska fakulteten (OD) (creator_code:org_t)
SPIE - International Society for Optical Engineering, 2017
2017
English.
In: Developments in X-Ray Tomography XI. - : SPIE - International Society for Optical Engineering. ; 10391
  • Conference paper (peer-reviewed)
Abstract Subject headings
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  • Permanent implants made of titanium or its alloys are the gold standard in many orthopedic and traumatological applications due to their good biocompatibility and mechanical properties. However, a second surgical intervention is required for this kind of implants as they have to be removed in the case of children that are still growing or on patient's demand. Therefore, magnesium-based implants are considered for medical applications as they are degraded under physiological conditions. The major challenge is tailoring the degradation in a manner that is suitable for a biological environment and such that stabilization of the bone is provided for a controlled period. In order to understand failure mechanisms of magnesium-based implants in orthopedic applications and, further, to better understand the osseointegration, screw implants in bone are studied under mechanical load by means of a push-out device installed at the imaging beamline P05 of PETRA III at DESY. Conventional absorption contrast microtomography and phasecontrast techniques are applied in order to monitor the bone-to-implant interface under increasing load conditions. In this proof-of-concept study, first results from an in situ push-out experiment are presented.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
NATURVETENSKAP  -- Fysik -- Annan fysik (hsv//swe)
NATURAL SCIENCES  -- Physical Sciences -- Other Physics Topics (hsv//eng)

Keyword

Magnesium alloys
biodegradation
biodegradable metallic implants
bone-implant-interface
bone healing
X-ray tomography
synchrotron radiation
microCT
in situ mechanical testing
load frame
Biodegradable metallic implants
Biodegradation
Bone healing
Bone-implant-interface
In situ mechanical testing
Load frame
Magnesium alloys
MicroCT
Synchrotron radiation
X-ray tomography

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