Biofuel cell based on microscale nanostructured electrodes with inductive coupling to rat brain neurons

Miniature, self-contained biodevices powered by biofuel cells may enable a new generation of implantable, wireless, minimally invasive neural interfaces for neurophysiological in vivo studies and for clinical applications. Here we report on the fabrication of a direct electron transfer based glucose/oxygen enzymatic fuel cell (EFC) from genuinely three-dimensional (3D) nanostructured microscale gold electrodes, modified with suitable biocatalysts. We show that the process underlying the simple fabrication method of 3D nanostructured electrodes is based on an electrochemically driven transformation of physically deposited gold nanoparticles. We experimentally demonstrate that mediator-, cofactor-, and membrane-less EFCs do operate in cerebrospinal fluid and in the brain of a rat, producing amounts of electrical power sufficient to drive a self-contained biodevice, viz. 7 μW cm−2 in vitro and 2 μW cm−2 in vivo at an operating voltage of 0.4 V. Last but not least, we also demonstrate an inductive coupling between 3D nanobioelectrodes and living neurons.

Falk, MagnusMalmö University,Malmö högskola,Institutionen för biomedicinsk vetenskap (BMV)(Swepub:mau)hsmafa (author)
Suyatin, DmitryLund University,Lunds universitet,Neuronano Research Center (NRC),Forskargrupper vid Lunds universitet,Fasta tillståndets fysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Lund University Research Groups,Solid State Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)ftf-dsu (author)
Granmo, MarcusLund University,Lunds universitet,Neurofysiologi,Forskargrupper vid Lunds universitet,Neuronano Research Center (NRC),Neurophysiology,Lund University Research Groups(Swepub:lu)mphy-mgr (author)
Sotres, JavierMalmö University,Malmö högskola,Institutionen för biomedicinsk vetenskap (BMV)(Swepub:mau)hsjaso (author)
Ludwig, RolandUniversity of Natural Resources and Life Sciences, Vienna (author)
Popov, VladimirBach Institute of Biochemistry,Russian Research Center 'Kurchatov Institute' (author)
Schouenborg, JensLund University,Lunds universitet,Neurofysiologi,Forskargrupper vid Lunds universitet,Neuronano Research Center (NRC),Neurophysiology,Lund University Research Groups(Swepub:lu)mphy-jsc (author)
Blum, ZoltanMalmö University,Malmö högskola,Institutionen för biomedicinsk vetenskap (BMV)(Swepub:mau)tszobl (author)
Sergey, ShleevMalmö University,Bach Institute of Biochemistry (author)
Malmö UniversityInstitutionen för biomedicinsk vetenskap (BMV) (creator_code:org_t)

By the author/editor: Andoralov, Vikto ...; Falk, Magnus; Suyatin, Dmitry; Granmo, Marcus; Sotres, Javier; Ludwig, Roland; show more...; Popov, Vladimir; Schouenborg, Jen ...; Blum, Zoltan; Sergey, Shleev; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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