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Interfacing antibody-based microarrays and digital holography enables label-free detection for loss of cell volume
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- El-Schich, Zahra (author)
- Malmö University,Malmö högskola,Institutionen för biomedicinsk vetenskap (BMV)
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- Nilsson, Emmy (author)
- Malmö University,Malmö högskola,Institutionen för biomedicinsk vetenskap (BMV)
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- Sandström Gerdtsson, Anna (author)
- Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH
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- (creator_code:org_t)
- Future Science Group, 2015
- 2015
- English.
- In: Future Science OA. - : Future Science Group. - 2056-5623. ; 1:3
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Background: We introduce the combination of digital holographic microscopy (DHM) and antibody microarrays as a powerful tool to measure morphological changes in specifically antibody-captured cells. The aim of the study was to develop DHM for analysis of cell death of etoposide-treated suspension cells. Result/Methodology: We demonstrate that the cell number, mean area, thickness, and volume were non-invasively measured by using DHM. The cell number was stable over time, but the two cell lines showed changes of cell area and cell irregularity after treatment. The cell volume in etoposide-treated cells was decreased, whereas untreated cells showed stable volume. Conclusions: Our results provide proof of concept for using DHM combined with antibody-based microarray technology for detecting morphological changes in captured cells.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- antibody
- cellular
- holography
- microarray
- volume
Publication and Content Type
- ref (subject category)
- art (subject category)
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