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The effect of magne...
The effect of magnesium on early osseointegration in osteoporotic bone : a histological and gene expression investigation
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- Galli, Silvia (author)
- Malmö högskola,Odontologiska fakulteten (OD),Malmö universitet,Malmö university
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- Stocchero, Michele (author)
- Malmö högskola,Odontologiska fakulteten (OD),Malmö universitet,Malmö university
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- Andersson, Martin, 1974 (author)
- Department of Chemistry and Chemical Engineering, Applied Chemistry, Chalmers University of Technology, 412 96, Gothenburg, Sweden,Chalmers tekniska högskola,Chalmers University of Technology
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- Karlsson, Johan, 1984 (author)
- Department of Chemistry and Chemical Engineering, Applied Chemistry, Chalmers University of Technology, 412 96, Gothenburg, Sweden,Chalmers tekniska högskola,Chalmers University of Technology
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- He, Wenxiao, 1985 (author)
- Department of Chemistry and Chemical Engineering, Applied Chemistry, Chalmers University of Technology, 412 96, Gothenburg, Sweden,Chalmers tekniska högskola,Chalmers University of Technology
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- Lilin, T. (author)
- Center for Biomedical Research, ECole Nationale Vétérinaire d'Alfort, 94700, Maisons Alfort, France,Ecole Nationale Veterinaire d'Alfort
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- Wennerberg, Ann (author)
- Malmö högskola,Odontologiska fakulteten (OD),Malmö universitet,Malmö university
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- Jimbo, Ryo (author)
- Malmö högskola,Odontologiska fakulteten (OD),Malmö universitet,Malmö university
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(creator_code:org_t)
- 2017-03-27
- 2017
- English.
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In: Osteoporosis International. - : Springer. - 0937-941X .- 1433-2965. ; 28:7, s. 2195-2205
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Abstract
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- Magnesium has a key role in osteoporosis and could enhance implant osseointegration in osteoporotic patients. Titanium implants impregnated with Mg ions were installed in the tibia of ovariectomized rats. The release of Mg induced a significant increase of bone formation and the expression of anabolic markers in the peri-implant bone. The success of endosseous implants is highly predictable in patients possessing normal bone status, but it may be impaired in patients with osteoporosis. Thus, the application of strategies that adjuvate implant healing in compromized sites is of great interest. Magnesium has a key role in osteoporosis prevention and it is an interesting candidate for this purpose. In this study, the cellular and molecular effects of magnesium release from implants were investigated at the early healing stages of implant integration. Osteoporosis was induced in 24 female rats by means of ovariectomy and low-calcium diet. Titanium mini-screws were coated with mesoporous titania films and were loaded with magnesium (test group) or left as native (control group). The implants were inserted in the tibia and femur of the rats. One, 2 and 7 days after implantation, the implants were retrieved and histologically examined. In addition, expression of genes was evaluated in the peri-implant bone tissue at day 7 by means of quantitative polymerase chain reactions with pathway-oriented arrays. The histological evaluation revealed that new bone formation started already during the first week of healing for both groups. However, around the test implants, new bone was significantly more abundant and spread along a larger surface of the implants. In addition, the release of magnesium induced a significantly higher expression of BMP6. These results provide evidence that the release of magnesium promoted rapid bone formation and the activation of osteogenic signals in the vicinity of implants placed in osteoporotic bone.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Materials (hsv//eng)
Keyword
- Implant surface
- In vivo
- Magnesium
- Mesoporous titania
- Osseointegration
- Osteoporosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Galli, Silvia
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Stocchero, Miche ...
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Andersson, Marti ...
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Karlsson, Johan, ...
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He, Wenxiao, 198 ...
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Lilin, T.
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Wennerberg, Ann
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Jimbo, Ryo
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dentistry
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Medical Engineer ...
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and Medical Material ...
- Articles in the publication
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Osteoporosis Int ...
- By the university
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Malmö University
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Chalmers University of Technology