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QseC controls biofi...
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Ünal, CanLund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
(author)
QseC controls biofilm formation of non typeable Haemophilus influenzae in addition to an A1-2 dependent mechanism
- Article/chapterEnglish2012
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Elsevier,2012
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LIBRIS-ID:oai:DiVA.org:mau-15589
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https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-15589URI
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https://doi.org/10.1016/j.ijmm.2012.07.013DOI
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https://lup.lub.lu.se/record/3124231URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Non-typeable Haemophilus influenzae (NTHi) is a common pathogen associated with diseases such as acute otitis media or exacerbations in patients with chronic obstructive pulmonary disease. The biofilm-forming capability substantially contributes to the persistence of NTHi. However, the regulation of biofilm formation is not completely understood. Quorum sensing regulated by autoinducer-2 produced by luxS is until now the only described regulatory mechanism. In this study, we show that the two-component signalling system QseB/C is involved in the biofilm formation of NTHi in vitro. An isogenic NTHi mutant of qseC (Hi3655KR2) showed a significant decrease in biofilm formation under static and semi-static conditions as assessed by crystal violet staining. In addition, under constant flow conditions, Hi3655KR2 formed less biofilm after 48 h. The biofilm defects were irrespective of autoinducer-2 levels. Hence, here we suggest for the first time a regulatory circuit in NTHi, which controls biofilm formation by mechanisms other than or in addition to luxS-dependent factors.
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Singh, BirendraLund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups(Swepub:lu)med-bas
(author)
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Fleury, ChristopheLund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups(Swepub:lu)med-cof
(author)
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Singh, KalpanaLund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups(Swepub:lu)med-kps
(author)
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Chávez de Paz, LuisMalmö högskola,Odontologiska fakulteten (OD)(Swepub:mau)odluch
(author)
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Svensäter, GunnelMalmö högskola,Odontologiska fakulteten (OD)(Swepub:mau)odgusv
(author)
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Riesbeck, KristianLund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups(Swepub:lu)mikr-kri
(author)
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Klinisk mikrobiologi, MalmöForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
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In:International Journal of Medical Microbiology: Elsevier302:6, s. 261-2691438-42211618-0607
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