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Bacterial diversity...
Bacterial diversity in medication-related osteonecrosis of the jaw
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- Hallmer, Fredrik (author)
- Malmö högskola,Odontologiska fakulteten (OD),Department of Oral and Maxillofacial Surgery, Skåne University Hospital, Lund, Sweden
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- Bjørnland, Tore (author)
- Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway
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- Andersson, Gunilla (author)
- Malmö högskola,Odontologiska fakulteten (OD)
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- Becktor, Jonas P (author)
- Malmö högskola,Odontologiska fakulteten (OD)
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- Kristoffersen, Anne K. (author)
- Senior Engineer, Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway
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- Enersen, Morten (author)
- Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway
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(creator_code:org_t)
- Elsevier, 2017
- 2017
- English.
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In: Oral surgery, oral medicine, oral pathology and oral radiology. - : Elsevier. - 2212-4403 .- 2212-4411. ; 123:4, s. 436-444
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objective. The aim was to study the association between microflora and medication-related osteonecrosis of the jaw (MRONJ) by using culture-independent molecular techniques to detect bacteria in necrotic bone lesions. Study Design. Included were 18 consecutive patients with MRONJ, 10 with osteoporosis and 8 cancer patients. Bone biopsies were retrieved from the center of the necrotic bone and from visually healthy bone, and 16 S rRNA gene fragments from bacterial DNA were amplified with polymerase chain reaction. Results. The study revealed a diversity of bacteria represented by 16 S rRNA sequences in all the necrotic bone samples and in 60% of the visually healthy bone. Eight dominating taxa groups were identified at the genus level: Porphyromonas, Lactobacillus, Tannerella, Prevotella, Actinomyces, Treponema, Streptococcus, and Fusobacterium. Conclusions. The necrotic bone lesions contained mainly anaerobic bacteria, representative of periodontal microflora, suggesting that a periodontal infection in combination with antiresorptive treatment could initiate osteonecrosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- Dentistry
- Oral Surgery & Medicine
- Adult
- Aged
- Aged
- 80 and over
- Bacteria
- Bacterial Typing Techniques
- Biopsy
- Bisphosphonate-Associated Osteonecrosis of the Jaw
- Female
- Humans
- Male
- Necrosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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