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Non-reversible heat...
Non-reversible heat-induced gelation of a biocompatible Fmoc-hexapeptide in water
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- Wojciechowski, Jonathan P. (author)
- School of Chemistry, The Australian Centre for Nanomedicine and the ARC Centre for Convergent Bio-Nano Science & Technology, University of New South Wales, Sydney, NSW 2052, Australia,Imperial College London
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- Martin, Adam D. (author)
- Dementia Research Centre, Department of Biomedical Science, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, 2109, NSW, Australia
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- Du, Eric Y. (author)
- School of Chemistry, Australian Centre for Nanomedicine, ARC Centre for Convergent Bio-Nano Science and Technology, University of New South Wales, Sydney, 2052, NSW, Australia
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- Garvey, Christopher J. (author)
- Malmö University,Lund University,Lunds universitet,Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Australian Nuclear Science and Technology Organisation, New Illawara Rd, Lucas Heights, 2231, NSW, Australia; Lund Institute for Advanced Neutron and X-ray Scattering, Lund, Sweden,LINXS - Institute of advanced Neutron and X-ray Science,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Nordon, Robert E. (author)
- Graduate School of Biomedical Engineering, University of New South Wales Sydney, Sydney, 2052, NSW, Australia
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- Thordarson, Pall (author)
- School of Chemistry, Australian Centre for Nanomedicine, ARC Centre for Convergent Bio-Nano Science and Technology, University of New South Wales, Sydney, 2052, NSW, Australia
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(creator_code:org_t)
- 2020
- 2020
- English.
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In: Nanoscale. - : Royal Society of Chemistry. - 2040-3364 .- 2040-3372. ; 12:15, s. 8262-8267
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Hydrogel materials which respond to changes in temperature are widely applicable for injectable drug delivery or tissue engineering applications. Here, we report the unsual heat-induced gelation behaviour of a low molecular weight gelator based on an Fmoc-hexapeptide, Fmoc-GFFRGD. We show that Fmoc-GFFRGD forms kinetically stable fibres when mixed with divalent cations (e.g. Ca2+). Gelation of the mixture occurs upon heating of the mixture which enables electrostatic screening by the divalent cations and hydrophobic collapse of the fibres to give a self-supporting hydrogel network that shows good biocompatibility with L929 fibroblast cells. This work highlights a unique mechanism to initiate heat-induced gelation which should find opportunities as a gelation trigger for injectable hydrogels or fundamental self-assembly applications.
Subject headings
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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