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Spontaneous Self-Assembly of Thermoresponsive Vesicles Using a Zwitterionic and an Anionic Surfactant

McCoy, Thomas M (author)
BP Institute and Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0EZ, United Kingdom; School of Chemistry, Monash University, Clayton 3800, Australia,Australian Nuclear Science and Technology Organisation
Marlow, Joshua B (author)
School of Chemistry, Monash University, Clayton 3800, Australia
Armstrong, Alexander J (author)
BP Institute and Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0EZ, United Kingdom
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Clulow, Andrew J (author)
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Parkville 3052, Australia,Australian Nuclear Science and Technology Organisation
Garvey, Christopher J. (author)
Malmö University,Lund University,Lunds universitet,Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Australian Centre for Neutron Scattering, ANSTO, Lucas Heights, New South Wales 2234, Australia; Lund Institute for Advanced Neutron and X-ray Scattering, Lund, Sweden,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Australian Nuclear Science and Technology Organisation
Manohar, Madhura (author)
National Deuteration Facility, ANSTO, Lucas Heights, New South Wales 2234, Australia
Darwish, Tamim A (author)
National Deuteration Facility, ANSTO, Lucas Heights, New South Wales 2234, Australia,Australian Nuclear Science and Technology Organisation
Boyd, Ben J (author)
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Parkville 3052, Australia; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia,Monash University
Routh, Alexander F (author)
BP Institute and Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0EZ, United Kingdom
Tabor, Rico F (author)
School of Chemistry, Monash University, Clayton 3800, Australia
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 (creator_code:org_t)
2020-06-29
2020
English.
In: Biomacromolecules. - : American Chemical Society (ACS). - 1525-7797 .- 1526-4602. ; 21:11, s. 4569-4576
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  • Journal article (peer-reviewed)
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  • Spontaneous formation of vesicles from the self-assembly of two specific surfactants, one zwitterionic (oleyl amidopropyl betaine, OAPB) and the other anionic (Aerosol-OT, AOT), is explored in water using small-angle scattering techniques. Two factors were found to be critical in the formation of vesicles: surfactant ratio, as AOT concentrations less than equimolar with OAPB result in cylindrical micelles or mixtures of micellar structures, and salt concentration, whereby increasing the amount of NaCl promotes vesicle formation by reducing headgroup repulsions. Small-angle neutron scattering measurements reveal that the vesicles are approximately 30-40 nm in diameter, depending on sample composition. Small-angle X-ray scattering measurements suggest preferential partitioning of OAPB molecules on the vesicle inner layer to support vesicular packing. Heating the vesicles to physiological temperature (37 °C) causes them to collapse into smaller ellipsoidal micelles (2-3 nm), with higher salt concentrations (≥10 mM) inhibiting this transition. These aggregates could serve as responsive carriers for loading or unloading of aqueous cargoes such as drugs and pharmaceuticals, with temperature changes serving as a simple release/uptake mechanism.

Subject headings

NATURVETENSKAP  -- Kemi -- Fysikalisk kemi (hsv//swe)
NATURAL SCIENCES  -- Chemical Sciences -- Physical Chemistry (hsv//eng)

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