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  • Shou, KeyunJülich Centre for Neutron Science (JCNS-1) and Institute of Biological Information Processing (IBI-8: Neutron Scattering and Biological Matter), Forschungszentrum Jülich GmbH, 52428 Jülich, Germany; Institute of Physical Chemistry, RWTH Aachen University, Landoltweg 2, 52056 Aachen, Germany; Australian Nuclear Science and Technology Organisation, Lucas Heights, New South Wales 2234, Australia,Jülich Research Centre (author)

Effect of red blood cell shape changes on haemoglobin interactions and dynamics : a neutron scattering study

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-10-14
  • ROYAL SOC,2020
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:mau-37119
  • https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-37119URI
  • https://doi.org/10.1098/rsos.201507DOI
  • https://lup.lub.lu.se/record/019a69a5-1698-43df-ba5f-5178ecd6a6f2URI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • By using a combination of experimental neutron scattering techniques, it is possible to obtain a statistical perspective on red blood cell (RBC) shape in suspensions, and the inter-relationship with protein interactions and dynamics inside the confinement of the cell membrane. In this study, we examined the ultrastructure of RBC and protein-protein interactions of haemoglobin (Hb) in them using ultra-small-angle neutron scattering and small-angle neutron scattering (SANS). In addition, we used the neutron backscattering method to access Hb motion on the ns time scale and angstrom length scale. Quasi-elastic neutron scattering (QENS) experiments were performed to measure diffusive motion of Hb in RBCs and in an RBC lysate. By using QENS, we probed both internal Hb dynamics and global protein diffusion, on the accessible time scale and length scale by QENS. Shape changes of RBCs and variation of intracellular Hb concentration were induced by addition of the Na+-selective ionophore monensin and the K+-selective one, valinomycin. The experimental SANS and QENS results are discussed within the framework of crowded protein solutions, where free motion of Hb is obstructed by mutual interactions.

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  • Sarter, MonaJülich Centre for Neutron Science (JCNS-1) and Institute of Biological Information Processing (IBI-8: Neutron Scattering and Biological Matter), Forschungszentrum Jülich GmbH, 52428 Jülich, Germany; I. Physikalisches Institut (IA), AG Biophysik, RWTH Aachen, Sommerfeldstrasse 14, 52074 Aachen, Germany,Jülich Research Centre,RWTH Aachen University (author)
  • de Souza, Nicolas R.Australian Nuclear Science and Technology Organisation, Lucas Heights, New South Wales 2234, Australia (author)
  • de Campo, LilianaAustralian Nuclear Science and Technology Organisation, Lucas Heights, New South Wales 2234, Australia (author)
  • Whitten, Andrew E.Australian Nuclear Science and Technology Organisation, Lucas Heights, New South Wales 2234, Australia (author)
  • Kuchel, Philip W.School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia (author)
  • Garvey, Christopher J.Malmö University,Lund University,Lunds universitet,Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Australian Nuclear Science and Technology Organisation, Lucas Heights, New South Wales 2234, Australia; Lund Institute for Advanced Neutron and X-ray Science, Lund, Sweden,LINXS - Institute of advanced Neutron and X-ray Science,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)ch8532ga (author)
  • Stadler, Andreas M.Jülich Centre for Neutron Science (JCNS-1) and Institute of Biological Information Processing (IBI-8: Neutron Scattering and Biological Matter), Forschungszentrum Jülich GmbH, 52428 Jülich, Germany; Institute of Physical Chemistry, RWTH Aachen University, Landoltweg 2, 52056 Aachen, Germany,Jülich Research Centre (author)
  • Jülich Centre for Neutron Science (JCNS-1) and Institute of Biological Information Processing (IBI-8: Neutron Scattering and Biological Matter), Forschungszentrum Jülich GmbH, 52428 Jülich, Germany; Institute of Physical Chemistry, RWTH Aachen University, Landoltweg 2, 52056 Aachen, Germany; Australian Nuclear Science and Technology Organisation, Lucas Heights, New South Wales 2234, AustraliaJülich Research Centre (creator_code:org_t)

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  • In:Royal Society Open Science: ROYAL SOC7:102054-5703

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