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Time-resolved small...
Time-resolved small-angle neutron scattering as a probe for the dynamics of lipid exchange between human lipoproteins and naturally derived membranes
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- Maric, Selma (author)
- Malmö University,Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV)
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- Lind, Tania Kjellerup (author)
- Malmö University,Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV)
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- Raida, Manfred Roman (author)
- Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore
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- Bengtsson, Eva (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - matrix och inflammation i ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Matrix and Inflammation in Atherosclerosis,Lund University Research Groups
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- Fredrikson, Gunilla Nordin (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - matrix och inflammation i ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Matrix and Inflammation in Atherosclerosis,Lund University Research Groups
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- Rogers, Sarah (author)
- ISIS Science and Technology Facilities Council, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire, OX11 0QX, United Kingdom,ISIS Neutron and Muon Source
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- Moulin, Martine (author)
- Life Science Group, Institut Laue Langevin, 6, rue Jules Horowitz, BP 156, F-38042, Grenoble, Cedex 9, France
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- Haertlein, Michael (author)
- Life Science Group, Institut Laue Langevin, 6, rue Jules Horowitz, BP 156, F-38042, Grenoble, Cedex 9, France
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- Forsyth, V. Trevor (author)
- Life Science Group, Institut Laue Langevin, 6, rue Jules Horowitz, BP 156, F-38042, Grenoble, Cedex 9, France; Faculty of Natural Science and Institute for Science and Technology in Medicine, Keele University, Staffordshire, ST5 5BG, United Kingdom
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- Wenk, Markus R. (author)
- Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore
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- Pomorski, Thomas Guenther (author)
- Dept. of Plant and Environmental Sciences, University of Copenhagen, Thorvaldsensvej 40, 1871, Frederiksberg C, Denmark; Dept. of Molecular Biochemistry, Ruhr University Bochum, Faculty of Chemistry and Biochemistry, 44780, Bochum, Germany
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- Arnebrant, Thomas (author)
- Malmö University,Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV)
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- Lund, Reidar (author)
- Dept. of Chemistry, University of Oslo, Blindern, 0315, Oslo, Norway
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- Cárdenas, Marité (author)
- Malmö University,Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV)
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(creator_code:org_t)
- 2019-05-20
- 2019
- English.
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In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 9:1
- Related links:
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https://doi.org/10.1...
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https://mau.diva-por... (primary) (Raw object)
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https://www.nature.c...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Atherosclerosis is the main killer in the western world. Today's clinical markers include the total level of cholesterol and high-/low-density lipoproteins, which often fails to accurately predict the disease. The relationship between the lipid exchange capacity and lipoprotein structure should explain the extent by which they release or accept lipid cargo and should relate to the risk for developing atherosclerosis. Here, small-angle neutron scattering and tailored deuteration have been used to follow the molecular lipid exchange between human lipoprotein particles and cellular membrane mimics made of natural, "neutron invisible" phosphatidylcholines. We show that lipid exchange occurs via two different processes that include lipid transfer via collision and upon direct particle tethering to the membrane, and that high-density lipoprotein excels at exchanging the human-like unsaturated phosphatidylcholine. By mapping the specific lipid content and level of glycation/oxidation, the mode of action of specific lipoproteins can now be deciphered. This information can prove important for the development of improved diagnostic tools and in the treatment of atherosclerosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Multidisciplinary Sciences
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Maric, Selma
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Lind, Tania Kjel ...
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Raida, Manfred R ...
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Bengtsson, Eva
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Fredrikson, Guni ...
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Rogers, Sarah
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Moulin, Martine
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Haertlein, Micha ...
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Forsyth, V. Trev ...
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Wenk, Markus R.
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Pomorski, Thomas ...
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Arnebrant, Thoma ...
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Lund, Reidar
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Cárdenas, Marité
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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Malmö University
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Lund University