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Multimodal ex vivo ...
Multimodal ex vivo methods reveal that Gd-rich corrosion byproducts remain at the implant site of biodegradable Mg-Gd screws
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- Peruzzi, Niccolò (author)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Galli, Silvia (author)
- Malmö University,Malmö universitet,Odontologiska fakulteten (OD),Biofilms Research Center for Biointerfaces
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- Helmholz, Heike (author)
- Helmholtz-Zentrum hereon GmbH, Germany,Helmholtz-Zentrum Geesthacht
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- Kardjilov, Nikolay (author)
- Helmholtz Centre for Materials and Energy, Germany,Helmholtz-Zentrum Berlin für Materialien und Energie GmbH
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- Krüger, Diana (author)
- Helmholtz-Zentrum hereon GmbH, Germany,Helmholtz-Zentrum Geesthacht
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- Markötter, Henning (author)
- Bundesanstalt für Materialforschung und-prüfung, Germany,Federal Institute for Material Research and Testing (BAM) Germany
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- Moosmann, Julian (author)
- Helmholtz-Zentrum hereon GmbH, Germany,Helmholtz-Zentrum Geesthacht
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- Orlov, Dmytro (author)
- Lund University,Lunds universitet,Materialteknik,Institutionen för maskinvetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,Materials Engineering,Department of Mechanical Engineering Sciences,Departments at LTH,Faculty of Engineering, LTH
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- Prgomet, Zdenka (author)
- Malmö University,Malmö universitet,Odontologiska fakulteten (OD)
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- Willumeit-Römer, Regine (author)
- Helmholtz-Zentrum hereon GmbH, Germany,Helmholtz-Zentrum Geesthacht
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- Wennerberg, Ann, 1955 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för odontologi, sektion 2,Institute of Odontology, Section 2
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- Bech, Martin (author)
- Lund University,Lunds universitet,X-ray Phase Contrast,Forskargrupper vid Lunds universitet,Lund University Research Groups
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- English.
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In: Acta Biomaterialia. - : Elsevier. - 1742-7061 .- 1878-7568. ; 136, s. 582-591
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Abstract
Subject headings
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- Extensive research is being conducted on magnesium (Mg) alloys for bone implant manufacturing, due to their biocompatibility, biodegradability and mechanical properties. Gadolinium (Gd) is among the most promising alloying elements for property control in Mg alloy implants; however, its toxicity is controversial. Investigating Gd behavior during implant corrosion is thus of utmost importance. In this study, we analyzed the degradation byproducts at the implant site of biodegradable Mg-5Gd and Mg-10Gd implants after 12 weeks healing time, using a combination of different imaging techniques: histology, energy-dispersive x-ray spectroscopy (EDX), x-ray microcomputed tomography (µCT) and neutron µCT. The main finding has been that, at the healing time in exam, the corrosion appears to have involved only the Mg component, which has been substituted by calcium and phosphorus, while the Gd remains localized at the implant site. This was observed in 2D by means of EDX maps and extended to 3D with a novel application of neutron tomography. X-ray fluorescence analysis of the main excretory organs also did not reveal any measurable accumulation of Gd, further reinforcing the conclusion that very limited or no removal at all of Gd-alloy happened during degradation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Materialteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Materials Engineering (hsv//eng)
Keyword
- Molecular Biology
- Biomedical Engineering
- Biochemistry
- Biomaterials
- General Medicine
- Biotechnology
- Hälsa och samhälle
- Health and society
- Biodegradable implant
- Energy-dispersive x-ray spectroscopy
- Magnesium-gadolinium alloy
- Micro-computed tomography
- Multimodal analysis
- Absorbable Implants
- Alloys
- Bone Screws
- Corrosion
- Gadolinium
- Magnesium
- pharmacology
- Materials Testing
- X-Ray Microtomography
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Peruzzi, Niccolò
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Galli, Silvia
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Helmholz, Heike
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Kardjilov, Nikol ...
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Krüger, Diana
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Markötter, Henni ...
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show more...
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Moosmann, Julian
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Orlov, Dmytro
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Prgomet, Zdenka
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Willumeit-Römer, ...
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Wennerberg, Ann, ...
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Bech, Martin
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomaterials Sci ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dentistry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Orthopaedics
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Physical Science ...
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and Other Physics To ...
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Materials Engine ...
- Articles in the publication
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Acta Biomaterial ...
- By the university
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Malmö University
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Lund University
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University of Gothenburg