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  • Gudmundsson, PetriMalmö högskola,Fakulteten för hälsa och samhälle (HS) (author)

Quantitative detection of myocardial ischaemia by stress echocardiography; a comparison with SPECT

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009-06-18
  • BioMed Central,2009
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:mau-4731
  • https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-4731URI
  • https://doi.org/10.1186/1476-7120-7-28DOI
  • https://lup.lub.lu.se/record/1460082URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:119146896URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Aims: Real-time perfusion (RTP) adenosine stress echocardiography (ASE) can be used to visually evaluate myocardial ischaemia. The RTP power modulation technique angio-mode (AM), provides images for off-line perfusion quantification using Qontrast® software, generating values of peak signal intensity (A), myocardial blood flow velocity (β) and myocardial blood flow (Axβ). By comparing rest and stress values, their respective reserve values (A-r, β-r, Axβ-r) are generated. We evaluated myocardial ischaemia by RTP-ASE Qontrast® quantification, compared to visual perfusion evaluation with 99mTc-tetrofosmin singlephoton emission computed tomography (SPECT). Methods and Results: Patients admitted to SPECT underwent RTP-ASE (SONOS 5500) using AM during Sonovue® infusion, before and throughout adenosine stress, also used for SPECT. Visual myocardial perfusion and wall motion analysis, and Qontrast® quantification, were blindly compared to one another and to SPECT, at different time points off-line. We analyzed 201 coronary territories (left anterior descendent [LAD], left circumflex [LCx] and right coronary [RCA] artery territories) in 67 patients. SPECT showed ischaemia in 18 patients and 19 territories. Receiver operator characteristics and kappa values showed significant agreement with SPECT only for β-r and Axβ-r in all segments: area under the curve 0.678 and 0.665; P < 0.001 and < 0.01, respectively. The closest agreements were seen in the LAD territory: kappa 0.442 for both β-r and Axβ- r; P < 0.01. Visual evaluation of ischaemia showed good agreement with SPECT: accuracy 93%; kappa 0.67; P < 0.001; without non-interpretable territories. Conclusion: In this agreement study with SPECT, RTP-ASE Qontrast® quantification of myocardial ischaemia was less accurate and less feasible than visual evaluation and needs further development to be clinically useful.

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  • Shahgaldi, Kambiz (author)
  • Winter, ReidarKarolinska Institutet (author)
  • Dencker, MagnusLund University,Lunds universitet,Klinisk fysiologi och nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Physiology and Nuclear Medicine, Malmö,Lund University Research Groups(Swepub:lu)klin-mde (author)
  • Kitlinski, MariuszLund University,Lunds universitet,Obstetrisk, gynekologisk och prenatal ultraljudsdiagnostik,Forskargrupper vid Lunds universitet,Obstetric, Gynaecological and Prenatal Ultrasound Research,Lund University Research Groups(Swepub:lu)med-mzk (author)
  • Thorsson, OlaLund University,Lunds universitet,Klinisk fysiologi och nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Physiology and Nuclear Medicine, Malmö,Lund University Research Groups(Swepub:lu)klin-oth (author)
  • Willenheimer, Ronnie (author)
  • Ljunggren, LennartMalmö högskola,Fakulteten för hälsa och samhälle (HS)(Swepub:mau)hslelj (author)
  • Malmö högskolaFakulteten för hälsa och samhälle (HS) (creator_code:org_t)

Related titles

  • In:Cardiovascular Ultrasound: BioMed Central7:281476-7120

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