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Plasma circulating ...
Plasma circulating cell-free mitochondrial DNA in social anxiety disorder
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- Lindqvist, Daniel (author)
- Lund University,Lunds universitet,Enheten för Biologisk Psykiatri och Precisionspsykiatri,Forskargrupper vid Lunds universitet,Unit for Biological and Precision Psychiatry,Lund University Research Groups,Region Skåne
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- Furmark, Tomas (author)
- Uppsala universitet,Uppsala University,Institutionen för psykologi
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- Lavebratt, Catharina (author)
- Karolinska Institutet
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- Ohlsson, Lars (author)
- Malmö University,Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV)
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- Månsson, Kristoffer N T (author)
- Karolinska Institutet,Karolinska Institute
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Psychoneuroendocrinology. - : Elsevier. - 0306-4530 .- 1873-3360. ; 148
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Abstract
Subject headings
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- OBJECTIVE: To investigate plasma levels of circulating cell-free mitochondrial DNA (ccf-mtDNA) in patients with social anxiety disorder (SAD) and healthy controls (HC).METHODS: In this study, 88 participants (46 patients with SAD and 42 HCs) were enrolled and both ccf-mtDNA and peripheral blood mononuclear cells (PBMC) mtDNA copy number (mtDNA-cn) were measured at up to three times per individual (9-11 weeks apart). SAD patients also received cognitive behavioral therapy (CBT) between the second and third time-point.RESULTS: SAD patients had significantly lower ccf-mtDNA compared to HCs at all time points, but ccf-mtDNA did not change significantly after CBT, and was not associated with severity of anxiety symptoms. Plasma ccf-mtDNA did not significantly correlate with PBMC mtDNA-cn in patients.CONCLUSION: This is the first report of lower ccf-mtDNA in patients with an anxiety disorder. Our findings could reflect a more chronic illness course in SAD patients with prolonged periods of psychological stress leading to decreased levels of ccf-mtDNA, but future longitudinal studies are needed to confirm or refute this hypothesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Keyword
- Circulating cell-free mitochondrial DNA
- Cognitive behavioural therapy
- Social anxiety disorder
Publication and Content Type
- ref (subject category)
- art (subject category)
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