Search: onr:"swepub:oai:DiVA.org:mau-61999" >
Association of sali...
Association of salivary TREM-1 and PGLYRP1 inflammatory markers with non-communicable diseases.
-
- Silbereisen, Angelika (author)
- Section of Periodontology and Dental Prevention, Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden
-
- Lira-Junior, Ronaldo (author)
- Karolinska Institutet
-
- Åkerman, Sigvard (author)
- Malmö universitet,Odontologiska fakulteten (OD)
-
show more...
-
- Klinge, Björn (author)
- Malmö universitet,Odontologiska fakulteten (OD),Section of Periodontology and Dental Prevention, Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden
-
- Boström, Elisabeth A (author)
- Karolinska Institutet
-
- Bostanci, Nagihan (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- John Wiley & Sons, 2023
- 2023
- English.
-
In: Journal of Clinical Periodontology. - : John Wiley & Sons. - 0303-6979 .- 1600-051X. ; 50:11, s. 1467-1475
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://mau.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- AIM: Triggering receptor expressed on myeloid cells 1 (TREM-1) and peptidoglycan recognition protein 1 (PGLYRP1) are elevated in biofluids in the presence of various inflammatory conditions. This cross-sectional study aimed to evaluate the effect of age, sex, smoking and different oral and systemic non-communicable diseases on the levels of TREM-1 and PGLYRP1 in saliva.MATERIALS AND METHODS: In total, 445 individuals (mean age 48.7 ± 16.9 years, female:male 51%:49%) were included. All provided self-reported information on smoking and systemic diseases and whole stimulated saliva. Periodontal and cariological parameters were recorded. Salivary levels of TREM-1, PGLYRP1 and total protein were measured using commercially available assays.RESULTS: Salivary TREM-1 levels were significantly higher in stages III-IV periodontitis compared to other periodontal diagnoses (p < .05). Smoking, bleeding on probing (BOP), percentage of pockets ≥4 mm and the number of manifest caries were associated with TREM-1 (p < .05), while sex, BOP, number of manifest caries and muscle and joint diseases were associated with PGLYRP1 (p < .05).CONCLUSIONS: Salivary TREM-1 is associated with periodontitis and caries, while PGLYRP1 is associated with gingival inflammation and caries. Additionally, TREM-1 levels are modified by smoking, while PGLYRP1 is modified by sex and muscle and joint diseases. TREM-1 and PGLYRP1 in saliva could serve as potential biomarkers for detecting and monitoring non-communicable diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- PGLYRP1
- TREM-1
- caries
- non-communicable diseases
- periodontal disease
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database