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The Mutational Prof...
The Mutational Profile of Unicystic Ameloblastoma.
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- Heikinheimo, K (author)
- Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku and Turku University Hospital, Finland
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- Huhtala, J-M (author)
- Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku and Turku University Hospital, Finland
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- Thiel, A (author)
- Genome-Scale Biology, Research Programs Unit, University of Helsinki, Helsinki, Finland
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- Kurppa, K J (author)
- Department of Medical Biochemistry and Genetics and MediCity Research Laboratories, University of Turku, Turku, Finland
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- Heikinheimo, H (author)
- Chief Chief Technologies, Helsinki, Finland
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- Kovac, M (author)
- Bone Tumour Reference Centre at the Institute of Pathology, University Hospital Basel and University of Basel, Basel, Switzerland
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- Kragelund, C (author)
- Department of Oral Pathology and Medicine, Copenhagen, Denmark
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- Warfvinge, Gunnar (author)
- Malmö universitet,Odontologiska fakulteten (OD)
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- Dawson, H (author)
- Institute of Pathology, University of Bern, Bern, Switzerland
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- Elenius, K (author)
- Department of Medical Biochemistry and Genetics and MediCity Research Laboratories, University of Turku, Turku, Finland
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- Ristimäki, A (author)
- Genome-Scale Biology, Research Programs Unit, University of Helsinki, Helsinki, Finland; Department of Pathology, HUSLAB, Helsinki University Central Hospital, and Medicum, University of Helsinki, Finland
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- Baumhoer, D (author)
- Bone Tumour Reference Centre at the Institute of Pathology, University Hospital Basel and University of Basel, Basel, Switzerland
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- Morgan, P R (author)
- Head & Neck Pathology, King's College London, Guy's Hospital, London, UK
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(creator_code:org_t)
- 2018-09-14
- 2018
- English.
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In: Journal of Dental Research. - : Sage Publications. - 0022-0345 .- 1544-0591. ; 98:1, s. 54-60
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BRAF V600E is the most common mutation in conventional ameloblastoma (AM) of the mandible. In contrast, maxillary AMs appear to harbor more frequently RAS, FGFR2, or SMO mutations. Unicystic ameloblastoma (UAM) is considered a less aggressive variant of ameloblastoma, amenable to more conservative treatment, and classified as a distinct entity. The aim of this study was to characterize the mutation profile of UAM ( n = 39) and to compare it to conventional AM ( n = 39). The associations between mutation status and recurrence probability were also analyzed. In the mandible, 94% of UAMs (29/31, including 8/8 luminal, 6/8 intraluminal, and 15/15 mural subtypes) and 74% of AMs (28/38) revealed BRAF V600E mutations. Among the BRAF wild-type cases, 1 UAM showed a missense SMO mutation (p.L412F), whereas 2 NRAS (p.Q61R), 2 HRAS (p.Q61R), and 2 FGFR2 (p.C383R) activating mutations were identified in AM. Of the 3 maxillary UAMs, only 1 revealed a BRAF V600E mutation. Taken together, our findings demonstrate high frequency of activating BRAF V600E mutations in both UAM and AM of the mandible. In maxillary UAMs, the BRAF V600E mutation prevalence appears to be lower as was shown for AM previously. It could therefore be argued that UAM and AM are part of the spectrum of the same disease. AMs without BRAF V600E mutations were associated with an increased rate of local recurrence ( P = 0.0003), which might indicate that routine mutation testing also has an impact on prognosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- drug therapy
- genetic markers
- odontogenic tumors
- mitogen-activated protein kinase kinases
- jaw neoplasms
- survival analysis
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Heikinheimo, K
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Huhtala, J-M
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Thiel, A
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Kurppa, K J
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Heikinheimo, H
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Kovac, M
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Kragelund, C
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Warfvinge, Gunna ...
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Dawson, H
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Elenius, K
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Ristimäki, A
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Baumhoer, D
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Morgan, P R
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dentistry
- Articles in the publication
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Journal of Denta ...
- By the university
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Malmö University