onr:"swepub:oai:DiVA.org:mau-69946"
Search: onr:"swepub:oai:DiVA.org:mau-69946" > Patient safety of a...
- 1 of 1
- Previous record
- Next record
- To hitlist
Patient safety of adjunct pre-operative intravenous S-ketamine for pain relief in third molar surgery - a randomised, placebo-controlled, double-blind trial
-
- Eriksson, Lars B. (author)
- Uppsala Univ, Dept Surg Sci, Uppsala, Sweden; Uppsala Univ, Ctr Clin Res, Falun, Sweden; Falun Cty Hosp, Dept Oral & Maxillofacial Surg, S-79182 Falun, Sweden
-
- Gordh, Torsten (author)
- Uppsala Univ, Dept Surg Sci, Uppsala, Sweden
-
- Karlsten, Rolf (author)
- Uppsala Univ, Dept Surg Sci, Uppsala, Sweden
- show more...
- show less...
- (creator_code:org_t)
- 2024
- 2024
- English.
- In: BRITISH JOURNAL OF PAIN. - : Sage Publications. - 2049-4637.
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Purpose: To study patient safety in third molar surgery, where two different doses of S-ketamine were administered for pain relief and compared to a placebo (saline). The primary focus was capillary oxygen saturation of the blood (SpO(2)) and secondarily, alterations in respiratory rate, blood pressure, pulse or adverse events. Methods: One hundred and sixty-eight subjects were included in a randomised, placebo-controlled, double-blind trial. The two subanaesthetic study drugs were low-dose S-ketamine (0.125 mg/kg) and high-dose S-ketamine (0.25 mg/kg). Every patient was sedated with midazolam prior to infusion of the investigational drug. The teeth were surgically removed according to a routine clinical procedure, under local anaesthesia. Results: Primary end-point for the safety aspects was capillary oxygen saturation (SpO(2)) after administration of the investigational drug was finished. A significant difference was found between the placebo and the high-dose group at that point (p = .021), with a decrease of saturation in the high-dose group. The lowest saturation and the number of registrations of SpO(2) <90% did not show any difference between groups. Oxygen supplementation was given in circa 40% of the cases with no differences between the intervention groups. No other significant differences between groups regarding saturation or respiratory rate were noted. Conclusion: In this study, it was safe to use adjunct preoperative single-dose intravenous S-ketamine 0.25 mg/kg body weight for pain relief, in midazolam-sedated patients receiving third molar surgery. There were no serious adverse events or symptoms of overdose nor any clinically relevant effects on circulatory or respiratory parameters.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Keyword
- Adverse events
- physiological effects
- safety
- S-ketamine
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- BRITISH JOURNAL OF PAIN (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Eriksson, Lars B ...
- Gordh, Torsten
- Karlsten, Rolf
- Thor, Andreas
- Tegelberg, Ake
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Anesthesiology a ...
- Articles in the publication
- BRITISH JOURNAL ...
- By the university
- Malmö University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
