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Maltreatment, the O...
Maltreatment, the Oxytocin Receptor Gene, and Conduct Problems Among Male and Female Teenagers
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- Andreou, Dimitrios (author)
- Karolinska Institutet,Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden; 1st Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece
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- Comasco, Erika, 1982- (author)
- Uppsala universitet,Institutionen för neurovetenskap,Science for Life Laboratory, SciLifeLab
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- Åslund, Cecilia (author)
- Uppsala universitet,Centrum för klinisk forskning, Västerås
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- Nilsson, Kent W. (author)
- Uppsala universitet,Mälardalens högskola,Hälsa och välfärd,Uppsala Univ, Dept Neurosci, Ctr Clin Res, Vasteras, Sweden.,Centrum för klinisk forskning, Västerås
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- Hodgins, Sheilagh (author)
- Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Univ Montreal, Inst Univ Sante Mentale Montreal, Montreal, PQ, Canada.,Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden; Institut Universitaire en Santé Mentale de Montréal, Université de Montréal, Montreal, Canada
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(creator_code:org_t)
- 2018-03-22
- 2018
- English.
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In: Frontiers in Human Neuroscience. - : FRONTIERS MEDIA SA. - 1662-5161. ; 12
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Abstract
Subject headings
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- The oxytocin receptor gene (OXTR) influences human behavior. The G allele of OXTR rs53576 has been associated with both prosocial and maladaptive behaviors but few studies have taken account of environmental factors. The present study determined whether the association of childhood maltreatment with conduct problems was modified by OXTR rs53576 genotypes. In a general population sample of 1591 teenagers, conduct problems as well as maltreatment were measured by self-report. DNA was extracted from saliva samples. In males, there was a significant positive association between maltreatment and conduct problems independent of the genotype. In females, among G allele carriers, the level of conduct problems was significantly higher among those who had been maltreated as compared to those not maltreated. By contrast, among female AA carriers, conduct problems did not vary between those who were, and who were not, maltreated. The results indicate that OXTR rs53576 plays a role in antisocial behavior in females such that the G allele confers vulnerability for antisocial behavior if they experience maltreatment, whereas the A allele has a protective effect.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- oxytocin receptor gene
- rs53576
- maltreatment
- conduct problems
- gene-environment interaction
Publication and Content Type
- ref (subject category)
- art (subject category)
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