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Use of moist oral s...
Use of moist oral snuff (snus) and pancreatic cancer : Pooled analysis of nine prospective observational studies
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- Araghi, Marzieh (author)
- Karolinska Institute
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- Galanti, Maria Rosaria (author)
- Karolinska Institutet,Stockholm County Council
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- Lundberg, Michael (author)
- Karolinska Institutet,Karolinska Institute
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- Lager, Anton (author)
- Karolinska Institutet,Stockholm County Council
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- Engström, Gunnar (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Alfredsson, Lars (author)
- Karolinska Institutet,Karolinska Institute
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- Knutsson, Anders, 1942- (author)
- Mid Sweden University,Mittuniversitetet,Avdelningen för hälsovetenskap
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- Norberg, Margareta (author)
- Umeå University,Umeå universitet,Epidemiologi och global hälsa,Arcum,Umeå Univ, Umeå
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- Sund, Malin (author)
- Umeå University,Umeå universitet,Kirurgi,Umeå Univ, Umeå
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- Wennberg, Patrik (author)
- Umeå University,Umeå universitet,Allmänmedicin,Umeå Univ, Umeå
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- Lagerros, Ylva Trolle (author)
- Karolinska Institutet
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- Bellocco, Rino (author)
- Karolinska Institutet
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- Pedersen, Nancy L. (author)
- Karolinska Institutet
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- Östergren, Per Olof (author)
- Lund University,Lunds universitet,Socialmedicin och global hälsa,Forskargrupper vid Lunds universitet,Social Medicine and Global Health,Lund University Research Groups
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- Magnusson, Cecilia (author)
- Karolinska Institutet,Stockholm County Council
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(creator_code:org_t)
- 2017-05-19
- 2017
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 141:4, s. 687-693
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Abstract
Subject headings
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- While smoking is a well-established risk factor for pancreatic cancer, the effect of smokeless tobacco is less well understood. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess the association between Swedish snus use and the risk of pancreatic cancer. A total of 424,152 male participants from nine cohort studies were followed up for risk of pancreatic cancer through linkage to health registers. We used shared frailty models with random effects at the study level, to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for confounding factors. During 9,276,054 person-years of observation, 1,447 men developed pancreatic cancer. Compared to never-snus use, current snus use was not associated with risk of pancreatic cancer (HR 0.96, 95% CI 0.83-1.11) after adjustment for smoking. Swedish snus use does not appear to be implicated in the development of pancreatic cancer in men. Tobacco smoke constituents other than nicotine or its metabolites may account for the relationship between smoking and pancreatic cancer. What's new? While smoking is a well-established risk factor for pancreatic cancer, the effect of smokeless tobacco is less well understood. Smokeless tobacco like snus yields lower exposure to tobacco carcinogens compared with smoking, because it does not undergo combustion, but delivers an equivalent dose of nicotine. Using pooled individual data from the Swedish Collaboration on Health Effects of Snus Use, here the authors show that Swedish snus use does not appear to be implicated in the development of pancreatic cancer in men. Tobacco smoke constituents other than nicotine or its metabolites may account for the relationship between smoking and pancreatic cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- pancreatic cancer
- incidence
- snus
- Incidence
- Pancreatic cancer
- Snus
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Araghi, Marzieh
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Galanti, Maria R ...
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Lundberg, Michae ...
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Lager, Anton
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Engström, Gunnar
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Alfredsson, Lars
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Knutsson, Anders ...
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Norberg, Margare ...
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Sund, Malin
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Wennberg, Patrik
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Lagerros, Ylva T ...
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Bellocco, Rino
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Pedersen, Nancy ...
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Östergren, Per O ...
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Magnusson, Cecil ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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Mid Sweden University
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Umeå University
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Lund University
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Karolinska Institutet