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Exercise mitigates the loss of muscle mass by attenuating the activation of autophagy during severe energy deficit

Martin-Rincon, M. (author)
University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain
Pérez-López, A. (author)
University of Alcalá, Madrid, Spain
Morales-Alamo, D. (author)
University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain
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Perez-Suarez, I. (author)
University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain
de Pablos-Velasco, P. (author)
Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Canary Islands, Spain
Perez-Valera, M. (author)
University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain
Perez-Regalado, S. (author)
University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain
Martinez-Canton, M. (author)
University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain
Gelabert-Rebato, M. (author)
University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain
Juan-Habib, J. W. (author)
University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain
Holmberg, Hans-Christer, 1958- (author)
Mittuniversitetet,Institutionen för hälsovetenskap,Mittuniversitetet, Institutionen för hälsovetenskap
Calbet, J. A. L. (author)
University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain; The University of British Columbia, Vancouver, BC, Canada; The Norwegian School of Sport Sciences, Oslo, Norway
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 (creator_code:org_t)
2019-11-19
2019
English.
In: Nutrients. - : MDPI AG. - 2072-6643. ; 11:11
Related links:
https://doi.org/10.3...
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https://miun.diva-po... (primary) (Raw object)
https://www.mdpi.com...
https://urn.kb.se/re...
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https://urn.kb.se/re...
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  • Journal article (peer-reviewed)
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  • The loss of skeletal muscle mass with energy deficit is thought to be due to protein breakdown by the autophagy-lysosome and the ubiquitin-proteasome systems. We studied the main signaling pathways through which exercise can attenuate the loss of muscle mass during severe energy deficit (5500 kcal/day). Overweight men followed four days of caloric restriction (3.2 kcal/kg body weight day) and prolonged exercise (45 min of one-arm cranking and 8 h walking/day), and three days of control diet and restricted exercise, with an intra-subject design including biopsies from muscles submitted to distinct exercise volumes. Gene expression and signaling data indicate that the main catabolic pathway activated during severe energy deficit in skeletal muscle is the autophagy-lysosome pathway, without apparent activation of the ubiquitin-proteasome pathway. Markers of autophagy induction and flux were reduced by exercise primarily in the muscle submitted to an exceptional exercise volume. Changes in signaling are associated with those in circulating cortisol, testosterone, cortisol/testosterone ratio, insulin, BCAA, and leucine. We conclude that exercise mitigates the loss of muscle mass by attenuating autophagy activation, blunting the phosphorylation of AMPK/ULK1/Beclin1, and leading to p62/SQSTM1 accumulation. This includes the possibility of inhibiting autophagy as a mechanism to counteract muscle loss in humans under severe energy deficit. 

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences (hsv//eng)

Keyword

Autophagy-lysosome
Caloric restriction
Protein degradation
Skeletal muscle
Ubiquitin-proteasome

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ref (subject category)
art (subject category)

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