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Synthesis of amides...
Synthesis of amides and amines from aldehydes or ketones by heterogeneous metal catalysis
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- Afewerki, Samson, 1985- (author)
- Mittuniversitetet,Institutionen för naturvetenskap
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- Cordova, Armando, 1970- (author)
- Mittuniversitetet,Institutionen för naturvetenskap
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- Palo-Nieto, Carlos (author)
- Mittuniversitetet,Institutionen för naturvetenskap
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(creator_code:org_t)
- 2019
- English.
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- A mild and efficient synthesis of primary amines and amides from aldehydes or ketones using a heterogeneous metal catalyst and amine donor is disclosed. The initial heterogeneous metal-catalyzed reaction between the carbonyl and the amine donor components is followed by the addition of a suitable acylating agent component in one-pot, thus providing a catalytic one-pot three-component synthesis of amides. Integration of enzyme catalysis allows for eco-friendly one-pot co-catalytic synthesis of amides from aldehyde and ketone substrates, respectively. The process can be applied to asymmetric synthesis or to the co-catalytic one-pot three-component synthesis of capsaicin and its analogues from vanillin or vanillyl alcohol. A co-catalytic reductive amination/dynamic kinetic resolution (dkr) relay sequence for the asymmetric synthesis of optically active amides from ketones is disclosed. Implementation of a catalytic reductive amination/kinetic resolution (kr) relay sequence produces the corresponding optically active amide product and optical active primary amine product with the opposite stereochemistry from the starting ketones.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Publication and Content Type
- pop (subject category)
- pat (subject category)
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