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Vitamin D supplemen...
Vitamin D supplementation for the prevention of total cancer incidence and mortality : An updated systematic review and meta-analysis
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Cheema, Huzaifa Ahmad (author)
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Fatima, Maurish (author)
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Shahid, Abia (author)
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Bouaddi, Oumnia (author)
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Elgenidy, Anas (author)
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Rehman, Aqeeb Ur (author)
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Oussama Kacimi, Salah Eddine (author)
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Hasan, Mohammad Mehedi (author)
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- Lee, Ka Yiu (author)
- Mittuniversitetet,Institutionen för hälsovetenskaper (HOV),Swedish Winter Sports Research Centre
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Heliyon. - : Elsevier BV. - 2405-8440. ; 8:11
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- IntroductionPrevious randomized controlled trials (RCTs) and meta-analyses of RCTs evaluating vitamin D supplementation for the prevention of cancer incidence and mortality have found inconsistent results and no meta-analysis has assessed the quality of the evidence available. We, therefore, aimed to perform an updated meta-analysis by including recent large-scale RCTs and assessing the quality of the pooled evidence.MethodsWe searched several databases and trial registers from inception to April 2022. We used a random-effects model to estimate pooled risk ratios (RRs) and 95% confidence intervals (CIs). We used the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) considerations to evaluate the certainty of evidence.ResultsWe included 13 RCTs in our study. Vitamin D supplementation had no effect on the risk of total cancer incidence (RR 0.99, 95% CI: 0.94–1.04; I2 = 0%), total cancer mortality (RR 0.93, 95% CI: 0.84–1.03; I2 = 24%) and total mortality (RR 0.92, 95% CI: 0.82–1.04; I2 = 36%). The overall quality of evidence was high for all outcomes.DiscussionVitamin D supplementation is ineffective in reducing total cancer incidence and mortality in largely vitamin D-replete older adult populations. Future research should be based on populations with a higher prevalence of vitamin D deficiency and should involve more extended follow-up periods.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Meta-analysis
- Vitamin D supplements
- Cancer incidence
- Cancer mortality
Publication and Content Type
- ref (subject category)
- art (subject category)
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