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Antidiabetic and cy...
Antidiabetic and cytotoxic polyhydroxylated oleanane and ursane type triterpenoids from Salvia grossheimii
- Article/chapterEnglish2020
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Elsevier BV,2020
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LIBRIS-ID:oai:DiVA.org:miun-47333
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https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-47333URI
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https://doi.org/10.1016/j.bioorg.2020.104297DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
Notes
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Two polyhydroxylated oleanane and seven ursane triterpenoids were isolated from aerial parts of Salvia grossheimii. The chemical structures of the undescribed triterpenoids (1–6) were characterized using 1 and 2 D NMR and ESI-MS spectral data as; 2α, 3β, 11α –trihydroxy-olean-12- ene (1), 2α, 3β, 11α-trihydroxy-olean-18-ene (2), 2α- acetoxy-urs-12-ene-3β, 11α, 20β-triol (3), 3-keto-urs-12-ene-1β, 11α, 20β -triol (4), 2α, 3β-diacetoxy-urs-12-ene-1β, 11α, 20β -triol (5), and 3β-acetoxy-urs-12-ene-1β, 11α, 20β –triol (6). All compounds were evaluated for the in vitro α-glucosidase inhibitory and cytotoxic activities against MCF-7 human cancer cell line. Compounds 1, 2, 4, and 6 showed in vitro α-glucosidase inhibitory activity with IC50 = 43.6–198.4 µM, which were more potent than the antidiabetic medicine, acarbose. The remaining compounds; 3, and 7–9 showed potent cytotoxic activity (IC50 = 6.2–31.9 µM) against the cancerous cell line, while the potent α-glucosidase inhibitors were inactive. Molecular docking analysis and kinetic studies were applied to investigate the structure activity relationships and mechanisms of the human and Saccharomyces cerevisiae α-glucosidase inhibitory of the purified compounds. Comparing the high cytotoxicity and α-glucosidase inhibitory of the oleanane and ursane type triterpenoids suggest them as potential lead compounds for further research in anticancer and antidiabetic research.
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Mirkhani, Hossein
(author)
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Firuzi, Omidreza
(author)
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Moheimanian, Niloofar
(author)
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Asadollahi, Mojtaba
(author)
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Pirhadi, Somayeh
(author)
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Chandran, Jima N.
(author)
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Schneider, Bernd
(author)
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Jassbi, Amir Reza
(author)
Related titles
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In:Bioorganic chemistry: Elsevier BV1040045-2068
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