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Population Genomics...
Population Genomics Reveal Recent Speciation and Rapid Evolutionary Adaptation in Polar Bears
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Liu, Shiping (author)
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Lorenzen, Eline D. (author)
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Fumagalli, Matteo (author)
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Li, Bo (author)
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Harris, Kelley (author)
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Xiong, Zijun (author)
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Zhou, Long (author)
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Korneliussen, Thorfinn Sand (author)
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Somel, Mehmet (author)
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Babbitt, Courtney (author)
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Wray, Greg (author)
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Li, Jianwen (author)
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He, Weiming (author)
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Wang, Zhuo (author)
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Fu, Wenjing (author)
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Xiang, Xueyan (author)
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Morgan, Claire C. (author)
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Doherty, Aoife (author)
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O’Connell, Mary J. (author)
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McInerney, James O. (author)
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Born, Erik W. (author)
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- Dalén, Love (author)
- Naturhistoriska riksmuseet,Enheten för bioinformatik och genetik
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Dietz, Rune (author)
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Orlando, Ludovic (author)
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Sonne, Christian (author)
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Zhang, Guojie (author)
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Nielsen, Rasmus (author)
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Willerslev, Eske (author)
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Wang, Jun (author)
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: Cell. - : Elsevier BV. - 0092-8674 .- 1097-4172. ; 157:4, s. 785-794
- Related links:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Polar bears are uniquely adapted to life in the High Arctic and have undergone drastic physiological changes in response to Arctic climates and a hyper-lipid diet of primarily marine mammal prey. We analyzed 89 complete genomes of polar bear and brown bear using population genomic modeling and show that the species diverged only 479-343 thousand years BP. We find that genes on the polar bear lineage have been under stronger positive selection than in brown bears; nine of the top 16 genes under strong positive selection are associated with cardiomyopathy and vascular disease, implying important reorganization of the cardiovascular system. One of the genes showing the strongest evidence of selection, APOB, encodes the primary lipoprotein component of low-density lipoprotein (LDL); functional mutations in APOB may explain how polar bears are able to cope with life-long elevated LDL levels that are associated with high risk of heart disease in humans.
Subject headings
- NATURVETENSKAP -- Biologi -- Zoologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Zoology (hsv//eng)
Keyword
- Ecosystems and species history
- Ekosystem och arthistoria
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cell
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To the university's database
- By the author/editor
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Liu, Shiping
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Lorenzen, Eline ...
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Fumagalli, Matte ...
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Li, Bo
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Harris, Kelley
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Xiong, Zijun
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show more...
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Zhou, Long
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Korneliussen, Th ...
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Somel, Mehmet
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Babbitt, Courtne ...
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Wray, Greg
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Li, Jianwen
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He, Weiming
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Wang, Zhuo
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Fu, Wenjing
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Xiang, Xueyan
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Morgan, Claire C ...
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Doherty, Aoife
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O’Connell, Mary ...
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McInerney, James ...
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Born, Erik W.
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Dalén, Love
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Dietz, Rune
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Orlando, Ludovic
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Sonne, Christian
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Zhang, Guojie
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Nielsen, Rasmus
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Willerslev, Eske
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Wang, Jun
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Zoology
- Articles in the publication
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Cell
- By the university
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Swedish Museum of Natural History