Search: onr:"swepub:oai:DiVA.org:nrm-4084" >
Genomic Adaptations...
Genomic Adaptations and Evolutionary History of the Extinct Scimitar-Toothed Cat, Homotherium latidens
- Article/chapterEnglish2020
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:DiVA.org:nrm-4084
-
https://urn.kb.se/resolve?urn=urn:nbn:se:nrm:diva-4084URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Summary Homotherium was a genus of large-bodied scimitar-toothed cats, morphologically distinct from any extant felid species, that went extinct at the end of the Pleistocene [1, 2, 3, 4]. They possessed large, saber-form serrated canine teeth, powerful forelimbs, a sloping back, and an enlarged optic bulb, all of which were key characteristics for predation on Pleistocene megafauna [5]. Previous mitochondrial DNA phylogenies suggested that it was a highly divergent sister lineage to all extant cat species [6, 7, 8]. However, mitochondrial phylogenies can be misled by hybridization [9], incomplete lineage sorting (ILS), or sex-biased dispersal patterns [10], which might be especially relevant for Homotherium since widespread mito-nuclear discrepancies have been uncovered in modern cats [10]. To examine the evolutionary history of Homotherium, we generated a ∼7x nuclear genome and a ∼38x exome from H. latidens using shotgun and target-capture sequencing approaches. Phylogenetic analyses reveal Homotherium as highly divergent (∼22.5 Ma) from living cat species, with no detectable signs of gene flow. Comparative genomic analyses found signatures of positive selection in several genes, including those involved in vision, cognitive function, and energy consumption, putatively consistent with diurnal activity, well-developed social behavior, and cursorial hunting [5]. Finally, we uncover relatively high levels of genetic diversity, suggesting that Homotherium may have been more abundant than the limited fossil record suggests [3, 4, 11, 12, 13, 14]. Our findings complement and extend previous inferences from both the fossil record and initial molecular studies, enhancing our understanding of the evolution and ecology of this remarkable lineage.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Westbury, Michael V.
(author)
-
Sandoval-Velasco, Marcela
(author)
-
Vieira, Filipe Garrett
(author)
-
Jeon, Sungwon
(author)
-
Zazula, Grant
(author)
-
Martin, Michael D.
(author)
-
Ho, Simon Y.W.
(author)
-
Mather, Niklas
(author)
-
Gopalakrishnan, Shyam
(author)
-
Ramos-Madrigal, Jazmín
(author)
-
de Manuel, Marc
(author)
-
Zepeda-Mendoza, M. Lisandra
(author)
-
Antunes, Agostinho
(author)
-
Baez, Aldo Carmona
(author)
-
De Cahsan, Binia
(author)
-
Larson, Greger
(author)
-
O’Brien, Stephen J.
(author)
-
Eizirik, Eduardo
(author)
-
Johnson, Warren E.
(author)
-
Koepfli, Klaus-Peter
(author)
-
Wilting, Andreas
(author)
-
Fickel, Jörns
(author)
-
Dalén, LoveNaturhistoriska riksmuseet,Enheten för bioinformatik och genetik(Swepub:nrm)lovedale
(author)
-
Lorenzen, Eline D.
(author)
-
Marques-Bonet, Tomas
(author)
-
Hansen, Anders J.
(author)
-
Zhang, Guojie
(author)
-
Bhak, Jong
(author)
-
Yamaguchi, Nobuyuki
(author)
-
Gilbert, M. Thomas P.
(author)
-
Naturhistoriska riksmuseetEnheten för bioinformatik och genetik
(creator_code:org_t)
Related titles
-
In:Current Biology0960-98221879-0445
Internet link
Find in a library
To the university's database
- By the author/editor
-
Barnett, Ross
-
Westbury, Michae ...
-
Sandoval-Velasco ...
-
Vieira, Filipe G ...
-
Jeon, Sungwon
-
Zazula, Grant
-
show more...
-
Martin, Michael ...
-
Ho, Simon Y.W.
-
Mather, Niklas
-
Gopalakrishnan, ...
-
Ramos-Madrigal, ...
-
de Manuel, Marc
-
Zepeda-Mendoza, ...
-
Antunes, Agostin ...
-
Baez, Aldo Carmo ...
-
De Cahsan, Binia
-
Larson, Greger
-
O’Brien, Stephen ...
-
Eizirik, Eduardo
-
Johnson, Warren ...
-
Koepfli, Klaus-P ...
-
Wilting, Andreas
-
Fickel, Jörns
-
Dalén, Love
-
Lorenzen, Eline ...
-
Marques-Bonet, T ...
-
Hansen, Anders J ...
-
Zhang, Guojie
-
Bhak, Jong
-
Yamaguchi, Nobuy ...
-
Gilbert, M. Thom ...
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Evolutionary Bio ...
- Articles in the publication
-
Current Biology
- By the university
-
Swedish Museum of Natural History