The impact of bariatric surgery on disease activity and progression of multiple sclerosis: A nationwide matched cohort study

The impact of bariatric surgery on disease activity and progression of multiple sclerosis : A nationwide matched cohort study

Anna Karin, Hedström (author): Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

Stenberg, Erik, 1979- (author): Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of surgery

Tim, Spelman (author): Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

Lars, Forsberg (author): Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

Erik, Näslund (author): Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden

Jan, Hillert (author): Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

(creator_code:org_t)

2022-07-07
2022
English.
In: Multiple Sclerosis Journal. - : Sage Publications. - 1352-4585 .- 1477-0970. ; 28:13, s. 2099-2105

Related links:: https://doi.org/10.1...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; show less...

Abstract Subject headings

BACKGROUND: Surgical outcomes in patients with multiple sclerosis (MS) following metabolic surgery appear to be similar compared to those of the general bariatric population.OBJECTIVE: To study the impact of metabolic surgery on the clinical course of MS.METHODS: Using data from the Scandinavian Obesity Surgery Registry and the Swedish Multiple Sclerosis register, we compared disease outcomes in 122 cases of MS who had undergone metabolic surgery with those of 122 cases of MS without surgery, matched by a two-staged Propensity score match, including age at disease onset, sex, MS phenotype, body mass index, and preoperative severity of MS as measured by the Expanded Disability Status Scale.RESULTS: The time to 6-month confirmed disability progression during the first five years postbaseline was shorter among the surgical patients (hazard ratio (HR) = 2.31, 95% confidence interval (CI) = 1.09-4.90; p = 0.03). No differences were observed regarding postoperative annual relapse rate (p = 0.24) or time to first postoperative relapse (p = 0.52).CONCLUSION: Although metabolic surgery appears to be a safe and efficient treatment of obesity in patients with MS, the clinical course of the disease might be negatively affected. Long-term nutritional follow-up after surgery and supplementation maintenance are crucial, particularly among those with preoperative deficits.

By the author/editor: Anna Karin, Heds ...; Stenberg, Erik, ...; Tim, Spelman; Lars, Forsberg; Erik, Näslund; Jan, Hillert

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

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